PDBsum entry 3zha

Chaperone

PDB id: 3zha

Contents

Protein chains

(+ 2 more) 380 a.a.

(+ 1 more) 18 a.a.

17 a.a.

16 a.a.

Ligands

SIN ×5

Waters ×222

PDB id:

3zha

Name:

Chaperone

Title:

Molecular basis for the action of the collagen-specific chaperone hsp47 serpinh1 and its structure-specific client recognition.

Structure:

Hsp47. Chain: a, b, c, d, k, l, p, q. Fragment: residues 36-418. Synonym: serpin peptidase inhibitor, clade h (heat shock protein 47), member 1, collagen binding protein 1. Engineered: yes. Collagen model peptide 18-t8r11. Chain: e, f, g, h, i, j, m, n, o, r, s, t. Engineered: yes

Source:

Canis lupus familiaris. Dog. Organism_taxid: 9615. Expressed in: escherichia coli. Expression_system_taxid: 511693. Synthetic: yes. Synthetic construct. Organism_taxid: 32630

Resolution:

2.55Å R-factor: 0.196 R-free: 0.218

Authors:

C.Widmer,J.M.Gebauer,U.Baumann

Key ref:

C.Widmer et al. (2012). Molecular basis for the action of the collagen-specific chaperone Hsp47/SERPINH1 and its structure-specific client recognition. Proc Natl Acad Sci U S A, 109, 13243-13247. PubMed id: 22847422

Date:

20-Dec-12 Release date: 09-Jan-13

Supersedes:

4awr

Protein chains

C7C419  (C7C419_CANLF) -  Serpin H1 from Canis lupus familiaris

Seq: 418 a.a.

Struc: 380 a.a.*

Protein chains

No UniProt id for this chain

Struc: 17 a.a.

Protein chains

No UniProt id for this chain

Struc: 16 a.a.

Protein chains

No UniProt id for this chain

Struc: 15 a.a.

* PDB and UniProt seqs differ at 1 residue position (black cross)

Proc Natl Acad Sci U S A 109:13243-13247 (2012)

PubMed id: 22847422

Molecular basis for the action of the collagen-specific chaperone Hsp47/SERPINH1 and its structure-specific client recognition.

C.Widmer, J.M.Gebauer, E.Brunstein, S.Rosenbaum, F.Zaucke, C.Drögemüller, T.Leeb, U.Baumann.

ABSTRACT

No abstract given.