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PDBsum entry 3vhu

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protein ligands links
Transcription/inhibitor PDB id
3vhu
Jmol
Contents
Protein chain
249 a.a.
Ligands
SNL
Waters ×62
PDB id:
3vhu
Name: Transcription/inhibitor
Title: Mineralocorticoid receptor ligand-binding domain with spiron
Structure: Mineralocorticoid receptor. Chain: a. Fragment: ligand-binding domain, unp residues 712-984. Synonym: mr, nuclear receptor subfamily 3 group c member 2. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nr3c2, mcr, mlr. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.11Å     R-factor:   0.193     R-free:   0.246
Authors: S.Sogabe,N.Habuka
Key ref: T.Hasui et al. (2011). Identification of benzoxazin-3-one derivatives as novel, potent, and selective nonsteroidal mineralocorticoid receptor antagonists. J Med Chem, 54, 8616-8631. PubMed id: 22074142 DOI: 10.1021/jm2011645
Date:
07-Sep-11     Release date:   28-Dec-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P08235  (MCR_HUMAN) -  Mineralocorticoid receptor
Seq:
Struc:
 
Seq:
Struc:
984 a.a.
249 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     nucleus   1 term 
  Biological process     steroid hormone mediated signaling pathway   2 terms 
  Biochemical function     DNA binding     3 terms  

 

 
DOI no: 10.1021/jm2011645 J Med Chem 54:8616-8631 (2011)
PubMed id: 22074142  
 
 
Identification of benzoxazin-3-one derivatives as novel, potent, and selective nonsteroidal mineralocorticoid receptor antagonists.
T.Hasui, N.Matsunaga, T.Ora, N.Ohyabu, N.Nishigaki, Y.Imura, Y.Igata, H.Matsui, T.Motoyaji, T.Tanaka, N.Habuka, S.Sogabe, M.Ono, C.S.Siedem, T.P.Tang, C.Gauthier, L.A.De Meese, S.A.Boyd, S.Fukumoto.
 
  ABSTRACT  
 
No abstract given.