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PDBsum entry 3vev

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protein ligands metals links
Transferase/transferase activator PDB id
3vev
Jmol
Contents
Protein chain
450 a.a.
Ligands
GLC
0H4
Metals
_NA
Waters ×362
PDB id:
3vev
Name: Transferase/transferase activator
Title: Glucokinase in complex with an activator and glucose
Structure: Glucokinase. Chain: a. Fragment: unp residues 12-465. Synonym: hexokinase type iv, hk iv, hexokinase-4, hk4, hexo engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gck. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
1.80Å     R-factor:   0.173     R-free:   0.200
Authors: S.Liu
Key ref: S.Liu et al. (2012). Insights into mechanism of glucokinase activation: observation of multiple distinct protein conformations. J Biol Chem, 287, 13598-13610. PubMed id: 22298776 DOI: 10.1074/jbc.M111.274126
Date:
09-Jan-12     Release date:   08-Feb-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P35557  (HXK4_HUMAN) -  Glucokinase
Seq:
Struc:
465 a.a.
450 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 8 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.2.7.1.2  - Glucokinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + D-glucose = ADP + D-glucose 6-phosphate
ATP
+
D-glucose
Bound ligand (Het Group name = GLC)
corresponds exactly
= ADP
+ D-glucose 6-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cytoplasm   7 terms 
  Biological process     metabolic process   35 terms 
  Biochemical function     catalytic activity     15 terms  

 

 
    reference    
 
 
DOI no: 10.1074/jbc.M111.274126 J Biol Chem 287:13598-13610 (2012)
PubMed id: 22298776  
 
 
Insights into mechanism of glucokinase activation: observation of multiple distinct protein conformations.
S.Liu, M.J.Ammirati, X.Song, J.D.Knafels, J.Zhang, S.E.Greasley, J.A.Pfefferkorn, X.Qiu.
 
  ABSTRACT  
 
No abstract given.