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PDBsum entry 3up1

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protein ligands Protein-protein interface(s) links
Immune system PDB id
3up1
Jmol
Contents
Protein chain
201 a.a.
Ligands
NAG-NAG ×2
FUC ×2
SO4 ×5
GOL ×4
NGA
Waters ×135
PDB id:
3up1
Name: Immune system
Title: Crystal structure of the unliganded human interleukin-7 rece extracellular domain
Structure: Interleukin-7 receptor subunit alpha. Chain: a, b. Synonym: il-7 receptor subunit alpha, il-7r subunit alpha, alpha, il-7ra, cdw127. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: il7r. Expressed in: drosophila. Expression_system_taxid: 32281.
Resolution:
2.15Å     R-factor:   0.217     R-free:   0.257
Authors: C.A.Mcelroy,P.J.Holland,S.T.R.Walsh
Key ref: C.A.McElroy et al. (2012). Structural reorganization of the interleukin-7 signaling complex. Proc Natl Acad Sci U S A, 109, 2503-2508. PubMed id: 22308406 DOI: 10.1073/pnas.1116582109
Date:
17-Nov-11     Release date:   08-Feb-12    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
P16871  (IL7RA_HUMAN) -  Interleukin-7 receptor subunit alpha
Seq:
Struc:
459 a.a.
201 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     membrane   1 term 
  Biochemical function     cytokine receptor activity     1 term  

 

 
DOI no: 10.1073/pnas.1116582109 Proc Natl Acad Sci U S A 109:2503-2508 (2012)
PubMed id: 22308406  
 
 
Structural reorganization of the interleukin-7 signaling complex.
C.A.McElroy, P.J.Holland, P.Zhao, J.M.Lim, L.Wells, E.Eisenstein, S.T.Walsh.
 
  ABSTRACT  
 
No abstract given.