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PDBsum entry 3sv1

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protein ligands Protein-protein interface(s) links
Protein binding PDB id
3sv1
Jmol
Contents
Protein chains
163 a.a.
143 a.a.
14 a.a.
11 a.a.
Ligands
GLY-TYR-GLU
Waters ×45
PDB id:
3sv1
Name: Protein binding
Title: Crystal structure of app peptide bound rat mint2 parm
Structure: Amyloid beta a4 precursor protein-binding family 2. Chain: a, b, c. Fragment: ptb and arm domains, residues 365-552. Synonym: adapter protein x11beta, neuron-specific x11l prot neuronal munc18-1-interacting protein 2, mint-2. Engineered: yes. Amyloid beta a4 protein. Chain: d, e, f.
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: mint2. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Homo sapiens. Human.
Resolution:
3.30Å     R-factor:   0.243     R-free:   0.301
Authors: Y.Shen,J.Long,X.Yan,X.Xie
Key ref: X.Xie et al. (2013). Open-closed motion of Mint2 regulates APP metabolism. J Mol Cell Biol, 5, 48-56. PubMed id: 22730553 DOI: 10.1093/jmcb/mjs033
Date:
12-Jul-11     Release date:   11-Jul-12    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
O35431  (APBA2_RAT) -  Amyloid beta A4 precursor protein-binding family A member 2
Seq:
Struc:
 
Seq:
Struc:
750 a.a.
163 a.a.*
Protein chains
Pfam   ArchSchema ?
O35431  (APBA2_RAT) -  Amyloid beta A4 precursor protein-binding family A member 2
Seq:
Struc:
 
Seq:
Struc:
750 a.a.
143 a.a.*
Protein chain
Pfam   ArchSchema ?
P05067  (A4_HUMAN) -  Amyloid beta A4 protein
Seq:
Struc:
 
Seq:
Struc:
770 a.a.
14 a.a.
Protein chain
Pfam   ArchSchema ?
P05067  (A4_HUMAN) -  Amyloid beta A4 protein
Seq:
Struc:
 
Seq:
Struc:
770 a.a.
11 a.a.
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 4 residue positions (black crosses)

 

 
DOI no: 10.1093/jmcb/mjs033 J Mol Cell Biol 5:48-56 (2013)
PubMed id: 22730553  
 
 
Open-closed motion of Mint2 regulates APP metabolism.
X.Xie, X.Yan, Z.Wang, H.Zhou, W.Diao, W.Zhou, J.Long, Y.Shen.
 
  ABSTRACT  
 
No abstract given.