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PDBsum entry 3rov

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protein ligands metals Protein-protein interface(s) links
Hormone PDB id
3rov
Jmol
Contents
Protein chains
(+ 0 more) 21 a.a.
(+ 0 more) 30 a.a.
Ligands
IPH ×6
Metals
_CL ×2
_ZN ×2
Waters ×186
PDB id:
3rov
Name: Hormone
Title: Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
Structure: Insulin. Chain: a, c, e, g, i, k. Synonym: insulin a chain. Engineered: yes. Insulin. Chain: b, d, f, h, j, l. Synonym: insulin b chain. Engineered: yes. Mutation: yes
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Other_details: this sequence occurs naturally in humans. Organism_taxid: 9606
Resolution:
2.30Å     R-factor:   0.218     R-free:   0.307
Authors: M.A.Weiss,Z.L.Wan,E.J.Dodson,M.Liu,B.Xu,Q.X.Hua,M.Turkenburg J.Whittingham,S.H.Nakagawa,K.Huang,S.Q.Hu,W.H.Jia,S.H.Wang, J.Whittaker,P.Arvan,P.G.Katsoyannis,G.G.Dodson
Key ref: M.A.Weiss et al. Insulin'S biosynthesis and activity have opposing str requirements: a new factor in neonatal diabetes melli. To be published, .
Date:
26-Apr-11     Release date:   02-May-12    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
P01308  (INS_HUMAN) -  Insulin
Seq:
Struc:
110 a.a.
21 a.a.
Protein chains
Pfam   ArchSchema ?
P01308  (INS_HUMAN) -  Insulin
Seq:
Struc:
110 a.a.
30 a.a.*
Key:    PfamA domain  Secondary structure
* PDB and UniProt seqs differ at 4 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular region   1 term 
  Biochemical function     hormone activity     1 term