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PDBsum entry 3qwr

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protein ligands Protein-protein interface(s) links
Protein binding/cytokine PDB id
3qwr
Jmol
Contents
Protein chains
295 a.a.
141 a.a.
91 a.a.
Ligands
NAG-NAG-BMA-MAN
Waters ×1
PDB id:
3qwr
Name: Protein binding/cytokine
Title: Crystal structure of il-23 in complex with an adnectin
Structure: Interleukin-12 subunit beta. Chain: a. Synonym: il-12b, cytotoxic lymphocyte maturation factor 40 subunit, clmf p40, il-12 subunit p40, nk cell stimulatory f chain 2, nksf2. Engineered: yes. Interleukin-23 subunit alpha. Chain: b. Synonym: il-23 subunit alpha, il-23-a, interleukin-23 subun
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: il12b, nksf2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: il23a, sgrf, unq2498/pro5798. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
3.25Å     R-factor:   0.235     R-free:   0.264
Authors: A.Wei,S.Sheriff
Key ref: V.Ramamurthy et al. (2012). Structures of adnectin/protein complexes reveal an expanded binding footprint. Structure, 20, 259-269. PubMed id: 22325775 DOI: 10.1016/j.str.2011.11.016
Date:
28-Feb-11     Release date:   01-Feb-12    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P29460  (IL12B_HUMAN) -  Interleukin-12 subunit beta
Seq:
Struc:
328 a.a.
295 a.a.
Protein chain
Pfam   ArchSchema ?
Q9NPF7  (IL23A_HUMAN) -  Interleukin-23 subunit alpha
Seq:
Struc:
189 a.a.
141 a.a.
Protein chain
No UniProt id for this chain
Struc: 91 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular region   6 terms 
  Biological process     negative regulation of growth of symbiont in host   64 terms 
  Biochemical function     protein binding     11 terms  

 

 
DOI no: 10.1016/j.str.2011.11.016 Structure 20:259-269 (2012)
PubMed id: 22325775  
 
 
Structures of adnectin/protein complexes reveal an expanded binding footprint.
V.Ramamurthy, S.R.Krystek, A.Bush, A.Wei, S.L.Emanuel, R.Das Gupta, A.Janjua, L.Cheng, M.Murdock, B.Abramczyk, D.Cohen, Z.Lin, P.Morin, J.H.Davis, M.Dabritz, D.C.McLaughlin, K.A.Russo, G.Chao, M.C.Wright, V.A.Jenny, L.J.Engle, E.Furfine, S.Sheriff.
 
  ABSTRACT  
 
No abstract given.