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PDBsum entry 3qs1
Go to PDB code:
Hydrolase/hydrolase inhibitor
PDB id
3qs1
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Contents
Protein chains
327 a.a.
Ligands
006
×4
GOL
×10
PDB id:
3qs1
Links
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CATH
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PDBePISA
ProSAT
Name:
Hydrolase/hydrolase inhibitor
Title:
Crystal structure of kni-10006 complex of plasmepsin i (pmi) from plasmodium falciparum
Structure:
Plasmepsin-1. Chain: a, b, c, d. Fragment: unp residues 117-452. Synonym: aspartic hemoglobinase i, pfapg. Engineered: yes
Source:
Plasmodium falciparum. Organism_taxid: 5833. Gene: pmi. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
3.10Å
R-factor:
0.215
R-free:
0.300
Authors:
P.Bhaumik,A.Gustchina,A.Wlodawer
Key ref:
P.Bhaumik et al. (2011). Crystal structures of the free and inhibited forms of plasmepsin I (PMI) from Plasmodium falciparum.
J Struct Biol
,
175
, 73-84.
PubMed id:
21521654
Date:
19-Feb-11
Release date:
11-May-11
PROCHECK
Headers
References
Protein chains
?
P39898
(PLM1_PLAFX) - Plasmepsin I from Plasmodium falciparum (isolate HB3)
Seq:
Struc:
452 a.a.
327 a.a.
Key:
PfamA domain
Secondary structure
CATH domain
Enzyme reactions
Enzyme class:
E.C.3.4.23.38
- plasmepsin I.
[IntEnz]
[ExPASy]
[KEGG]
[BRENDA]
Reaction:
Hydrolysis of the 33-Phe-|-Leu-34 bond in the alpha-chain of hemoglobin, leading to denaturation of molecule.
J Struct Biol
175
:73-84 (2011)
PubMed id:
21521654
Crystal structures of the free and inhibited forms of plasmepsin I (PMI) from Plasmodium falciparum.
P.Bhaumik,
Y.Horimoto,
H.Xiao,
T.Miura,
K.Hidaka,
Y.Kiso,
A.Wlodawer,
R.Y.Yada,
A.Gustchina.
ABSTRACT
No abstract given.
Links
