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PDBsum entry 3qkm

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protein ligands links
Transferase/transferase inhibitor PDB id
3qkm
Jmol
Contents
Protein chain
330 a.a.
Ligands
SM9
Waters ×308
PDB id:
3qkm
Name: Transferase/transferase inhibitor
Title: Spirocyclic sulfonamides as akt inhibitors
Structure: Rac-alpha serine/threonine-protein kinase. Chain: a. Fragment: kinase domain. Synonym: protein kinase b, pkb, proto-oncogenE C-akt, rac-p engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: akt1, pkb, rac. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Resolution:
2.20Å     R-factor:   0.191     R-free:   0.252
Authors: R.Xu,A.Banka,J.F.Blake,I.S.Mitchell,E.M.Wallace,S.L.Gloor, M.Martinson,T.Risom,S.D.Gross,T.Morales,G.P.A.Vigers,B.J.Br N.J.Skelton
Key ref: R.Xu et al. (2011). Discovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA. Bioorg Med Chem Lett, 21, 2335-2340. PubMed id: 21420856
Date:
01-Feb-11     Release date:   06-Apr-11    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P31749  (AKT1_HUMAN) -  RAC-alpha serine/threonine-protein kinase
Seq:
Struc:
480 a.a.
330 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 3 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     protein phosphorylation   1 term 
  Biochemical function     transferase activity, transferring phosphorus-containing groups     4 terms  

 

 
Bioorg Med Chem Lett 21:2335-2340 (2011)
PubMed id: 21420856  
 
 
Discovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA.
R.Xu, A.Banka, J.F.Blake, I.S.Mitchell, E.M.Wallace, J.R.Bencsik, N.C.Kallan, K.L.Spencer, S.L.Gloor, M.Martinson, T.Risom, S.D.Gross, T.H.Morales, W.I.Wu, G.P.Vigers, B.J.Brandhuber, N.J.Skelton.
 
  ABSTRACT  
 
No abstract given.