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PDBsum entry 3q05

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protein dna_rna metals Protein-protein interface(s) links
Antitumor protein/DNA PDB id
3q05
Jmol
Contents
Protein chains
234 a.a.
DNA/RNA
Metals
_ZN ×4
Waters ×161
PDB id:
3q05
Name: Antitumor protein/DNA
Title: An induced fit mechanism regulates p53 DNA binding kinetics sequence specificity
Structure: Cellular tumor antigen p53. Chain: a, b, c, d. Fragment: p53 DNA-binding (res 94-291) and oligomerization 356) domains. Synonym: antigen ny-co-13, phosphoprotein p53, tumor suppre engineered: yes. Mutation: yes. DNA (26-mer). Chain: k.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tp53, p53. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: consensus human tp53 binding sequence sense other_details: consensus human tp53 binding sequence anti-s
Resolution:
2.40Å     R-factor:   0.238     R-free:   0.267
Authors: T.J.Petty,T.D.Halazonetis
Key ref: T.J.Petty et al. (2011). An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. EMBO J, 30, 2167-2176. PubMed id: 21522129
Date:
15-Dec-10     Release date:   11-May-11    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
P04637  (P53_HUMAN) -  Cellular tumor antigen p53
Seq:
Struc:
393 a.a.
234 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 18 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     nucleus   1 term 
  Biological process     apoptotic process   3 terms 
  Biochemical function     transcription regulatory region DNA binding     3 terms  

 

 
EMBO J 30:2167-2176 (2011)
PubMed id: 21522129  
 
 
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
T.J.Petty, S.Emamzadah, L.Costantino, I.Petkova, E.S.Stavridi, J.G.Saven, E.Vauthey, T.D.Halazonetis.
 
  ABSTRACT  
 
No abstract given.