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PDBsum entry 3pxe

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protein ligands Protein-protein interface(s) links
Protein binding PDB id
3pxe
Jmol
Contents
Protein chain
211 a.a.
Ligands
SER-THR-SEP-PRO-
THR-PHE-ASN
SEP-PRO-THR-PHE-
ASN
THR-SEP-PRO-THR-
PHE-ASN
×2
Waters ×16
PDB id:
3pxe
Name: Protein binding
Title: Impact of brca1 brct domain missense substitutions on phosph recognition: e1836k
Structure: Breast cancer type 1 susceptibility protein. Chain: a, b, c, d. Fragment: brct domain, unp residues 1646-1859. Synonym: ring finger protein 53. Engineered: yes. Mutation: yes. Phospho peptide. Chain: e, f, g, h. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: brca1, rnf53. Expressed in: escherichia coli. Expression_system_taxid: 511693. Synthetic: yes. Other_details: peptide derived from brca1 partner bach1.
Resolution:
2.85Å     R-factor:   0.223     R-free:   0.266
Authors: N.Coquelle,R.Green,J.N.M.Glover
Key ref: N.Coquelle et al. (2011). Impact of BRCA1 BRCT domain missense substitutions on phosphopeptide recognition. Biochemistry, 50, 4579-4589. PubMed id: 21473589 DOI: 10.1021/bi2003795
Date:
09-Dec-10     Release date:   20-Apr-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P38398  (BRCA1_HUMAN) -  Breast cancer type 1 susceptibility protein
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
1863 a.a.
211 a.a.*
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     nucleus   1 term 
  Biological process     DNA repair   1 term 
  Biochemical function     DNA binding     3 terms  

 

 
DOI no: 10.1021/bi2003795 Biochemistry 50:4579-4589 (2011)
PubMed id: 21473589  
 
 
Impact of BRCA1 BRCT domain missense substitutions on phosphopeptide recognition.
N.Coquelle, R.Green, J.N.Glover.
 
  ABSTRACT  
 
No abstract given.