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PDBsum entry 3ps8

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protein ligands links
Hydrolase inhibitor PDB id
3ps8
Jmol
Contents
Protein chain
109 a.a.
Ligands
PEG ×3
ACT
Waters ×80
PDB id:
3ps8
Name: Hydrolase inhibitor
Title: Crystal structure of l68v mutant of human cystatin c
Structure: Cystatin-c. Chain: a. Synonym: cystatin-3, gamma-trace, neuroendocrine basic poly post-gamma-globulin. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cst3. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.55Å     R-factor:   0.191     R-free:   0.251
Authors: M.Orlikowska,D.Borek,Z.Otwinowski,P.Skowron,A.Szymanska
Key ref: M.Orlikowska et al. (2013). Structural characterization of V57D and V57P mutants of human cystatin C, an amyloidogenic protein. Acta Crystallogr D Biol Crystallogr, 69, 577-586. PubMed id: 23519666 DOI: 10.1107/S0907444912051657
Date:
01-Dec-10     Release date:   21-Dec-11    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P01034  (CYTC_HUMAN) -  Cystatin-C
Seq:
Struc:
146 a.a.
109 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular region   3 terms 
  Biological process     defense response   10 terms 
  Biochemical function     protein binding     6 terms  

 

 
DOI no: 10.1107/S0907444912051657 Acta Crystallogr D Biol Crystallogr 69:577-586 (2013)
PubMed id: 23519666  
 
 
Structural characterization of V57D and V57P mutants of human cystatin C, an amyloidogenic protein.
M.Orlikowska, A.SzymaƄska, D.Borek, Z.Otwinowski, P.Skowron, E.Jankowska.
 
  ABSTRACT  
 
No abstract given.