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PDBsum entry 3oui

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protein ligands metals links
Oxidoreductase PDB id
3oui
Jmol
Contents
Protein chain
190 a.a. *
Ligands
ACT ×2
42Z ×2
PEG
Metals
FE2
Waters ×99
* Residue conservation analysis
PDB id:
3oui
Name: Oxidoreductase
Title: Phd2-r717 with 40787422
Structure: Egl nine homolog 1. Chain: a. Synonym: hypoxia-inducible factor prolyl hydroxylase 2, hif hydroxylase 2, hif-ph2, hph-2, prolyl hydroxylase domain-co protein 2, phd2, sm-20. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egln1, c1orf12, pnas-118, pnas-137. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
1.70Å     R-factor:   0.190     R-free:   0.217
Authors: T.L.Arakaki,H.Kim
Date:
14-Sep-10     Release date:   01-Dec-10    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q9GZT9  (EGLN1_HUMAN) -  Egl nine homolog 1
Seq:
Struc:
426 a.a.
190 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.1.14.11.29  - Hypoxia-inducible factor-proline dioxygenase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2 = hypoxia- inducible factor-trans-4-hydroxy-L-proline + succinate + CO2
Hypoxia-inducible factor-L-proline
+ 2-oxoglutarate
+ O(2)
= hypoxia- inducible factor-trans-4-hydroxy-L-proline
+ succinate
+ CO(2)
      Cofactor: Fe(2+); L-ascorbate
Fe(2+)
L-ascorbate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     oxidation-reduction process   1 term 
  Biochemical function     oxidoreductase activity     5 terms