PDBsum entry 3oq5

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Transcription PDB id
Protein chains
309 a.a. *
MLZ ×2
Waters ×496
* Residue conservation analysis
PDB id:
Name: Transcription
Title: Crystal structure of the 3-mbt domain from human l3mbtl1 in with p53k382me1
Structure: Lethal(3)malignant brain tumor-like protein. Chain: a, b, c. Fragment: mbt repeats residues 191-530. Synonym: l(3)mbt-like, h-l(3)mbt protein, h-l(3)mbt, l(3)mb homolog, l3mbtl1. Engineered: yes. Cellular tumor antigen p53. Chain: d, e. Fragment: c-terminal residues 377-386.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: l3mbtl, kiaa0681, l3mbt, l3mbtl1. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: synthetic construct
2.50Å     R-factor:   0.207     R-free:   0.234
Authors: S.Roy,L.E.West,K.L.Weiner,R.Hayashi,X.Shi,E.Appella,O.Gozani T.Kutateladze
Key ref: L.E.West et al. (2010). The MBT repeats of L3MBTL1 link SET8-mediated p53 methylation at lysine 382 to target gene repression. J Biol Chem, 285, 37725-37732. PubMed id: 20870725
02-Sep-10     Release date:   22-Sep-10    
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Protein chains
Pfam   ArchSchema ?
Q9Y468  (LMBL1_HUMAN) -  Lethal(3)malignant brain tumor-like protein 1
752 a.a.
309 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     nucleus   1 term 
  Biological process     regulation of transcription, DNA-dependent   1 term 


J Biol Chem 285:37725-37732 (2010)
PubMed id: 20870725  
The MBT repeats of L3MBTL1 link SET8-mediated p53 methylation at lysine 382 to target gene repression.
L.E.West, S.Roy, K.Lachmi-Weiner, R.Hayashi, X.Shi, E.Appella, T.G.Kutateladze, O.Gozani.
No abstract given.


Literature references that cite this PDB file's key reference

  PubMed id Reference
22120668 K.Acs, M.S.Luijsterburg, L.Ackermann, F.A.Salomons, T.Hoppe, and N.P.Dantuma (2011).
The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks.
  Nat Struct Mol Biol, 18, 1345-1350.  
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