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PDBsum entry 3nx0

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protein ligands Protein-protein interface(s) links
Hydrolase inhibitor PDB id
3nx0
Jmol
Contents
Protein chains
109 a.a. *
Ligands
SO4 ×2
Waters ×173
* Residue conservation analysis
PDB id:
3nx0
Name: Hydrolase inhibitor
Title: Hinge-loop mutation can be used to control 3d domain swappin amyloidogenesis of human cystatin c
Structure: Cystatin-c. Chain: a, b. Fragment: unp residues 27-146. Synonym: cystatin-3, neuroendocrine basic polypeptide, gamm post-gamma-globulin. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cst3. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.04Å     R-factor:   0.181     R-free:   0.225
Authors: M.Orlikowska,E.Jankowska,R.Kolodziejczyk,M.Jaskolski,A.Szyma
Key ref: M.Orlikowska et al. (2011). Hinge-loop mutation can be used to control 3D domain swapping and amyloidogenesis of human cystatin C. J Struct Biol, 173, 406-413. PubMed id: 21074623 DOI: 10.1016/j.jsb.2010.11.009
Date:
12-Jul-10     Release date:   01-Dec-10    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P01034  (CYTC_HUMAN) -  Cystatin-C
Seq:
Struc:
146 a.a.
109 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular region   3 terms 
  Biological process     defense response   10 terms 
  Biochemical function     protein binding     6 terms  

 

 
DOI no: 10.1016/j.jsb.2010.11.009 J Struct Biol 173:406-413 (2011)
PubMed id: 21074623  
 
 
Hinge-loop mutation can be used to control 3D domain swapping and amyloidogenesis of human cystatin C.
M.Orlikowska, E.Jankowska, R.Kołodziejczyk, M.Jaskólski, A.Szymańska.
 
  ABSTRACT  
 
No abstract given.