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PDBsum entry 3nfp

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protein Protein-protein interface(s) links
Immune system/cytokine PDB id
3nfp
Jmol
Contents
Protein chains
213 a.a. *
212 a.a. *
124 a.a. *
111 a.a. *
Waters ×97
* Residue conservation analysis
PDB id:
3nfp
Name: Immune system/cytokine
Title: Crystal structure of the fab fragment of therapeutic antibod daclizumab in complex with il-2ra (cd25) ectodomain
Structure: Heavy chain of fab fragment of daclizumab. Chain: a, h. Engineered: yes. Light chain of fab fragment of daclizumab. Chain: b, l. Engineered: yes. Interleukin-2 receptor subunit alpha. Chain: i, k. Fragment: unp residues 22-238.
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: purchased from roche, expressed in a mammal expression system. Gene: il2ra. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: hi-5.
Resolution:
2.86Å     R-factor:   0.255     R-free:   0.301
Authors: H.Yang,J.Wang,J.Du,C.Zhong,Y.Guo,J.Ding
Key ref: H.Yang et al. (2010). Structural basis of immunosuppression by the therapeutic antibody daclizumab. Cell Res, 20, 1361-1371. PubMed id: 20820193
Date:
10-Jun-10     Release date:   15-Sep-10    
PROCHECK
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 Headers
 References

Protein chains
No UniProt id for this chain
Struc: 213 a.a.
Protein chains
No UniProt id for this chain
Struc: 212 a.a.
Protein chain
Pfam   ArchSchema ?
P01589  (IL2RA_HUMAN) -  Interleukin-2 receptor subunit alpha
Seq:
Struc:
272 a.a.
124 a.a.
Protein chain
Pfam   ArchSchema ?
P01589  (IL2RA_HUMAN) -  Interleukin-2 receptor subunit alpha
Seq:
Struc:
272 a.a.
111 a.a.
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain

 

 
Cell Res 20:1361-1371 (2010)
PubMed id: 20820193  
 
 
Structural basis of immunosuppression by the therapeutic antibody daclizumab.
H.Yang, J.Wang, J.Du, C.Zhong, D.Zhang, H.Guo, Y.Guo, J.Ding.
 
  ABSTRACT  
 
No abstract given.