PDBsum entry 3itr

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Interleukin-13 PDB id
Protein chain
109 a.a.
Theoretical model
PDB id:
Name: Interleukin-13
Structure: Interleukin-13 model 1 (theoretical model)
Source: Human (homo sapiens)
Authors: P.Bamborough,D.Duncan,W.G.Richards
Key ref: P.Bamborough et al. (1994). Predictive modelling of the 3-D structure of interleukin-13. Protein Eng, 7, 1077-1082. PubMed id: 7530359
06-Sep-94     Release date:   20-Dec-94    
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Protein chain
No UniProt id for this chain
Struc: 109 a.a.
Key:    Secondary structure


Protein Eng 7:1077-1082 (1994)
PubMed id: 7530359  
Predictive modelling of the 3-D structure of interleukin-13.
P.Bamborough, D.Duncan, W.G.Richards.
Several atomic structures are now available for the family of helical cytokines, which includes growth hormone as well as many of the interleukins. Using structural information from five members of this family, two alternative models of interleukin (IL)-13 are proposed. IL-13 has biological properties similar to those of IL-4 and, like the other interleukins, is a potentially important pharmaceutical target. The model of IL-13 is discussed and compared with the known interleukin structures.

Literature references that cite this PDB file's key reference

  PubMed id Reference
16957991 J.Ruan, K.Chen, J.A.Tuszynski, and L.A.Kurgan (2006).
Quantitative analysis of the conservation of the tertiary structure of protein segments.
  Protein J, 25, 301-315.  
  15626157 S.Avery, L.Rothwell, W.D.Degen, V.E.Schijns, J.Young, J.Kaufman, and P.Kaiser (2004).
Characterization of the first nonmammalian T2 cytokine gene cluster: the cluster contains functional single-copy genes for IL-3, IL-4, IL-13, and GM-CSF, a gene for IL-5 that appears to be a pseudogene, and a gene encoding another cytokinelike transcript, KK34.
  J Interferon Cytokine Res, 24, 600-610.  
11488979 J.Zuegg, D.C.Webb, P.S.Foster, and M.G.Casarotto (2001).
Structural model of human IL-13 defines the spatial interactions with the IL-13Ralpha/IL-4Ralpha receptor.
  Immunol Cell Biol, 79, 332-339.
PDB code: 1j9u
11418305 K.T.Nash, J.P.Thompson, and W.Debinski (2001).
Molecular targeting of malignant gliomas with novel multiply-mutated interleukin 13-based cytotoxins.
  Crit Rev Oncol Hematol, 39, 87-98.  
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