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PDBsum entry 3i2b

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protein ligands metals Protein-protein interface(s) links
Lyase PDB id
3i2b
Jmol
Contents
Protein chains
(+ 6 more) 138 a.a. *
Ligands
EDO
PEG
Metals
_MG ×2
_NI ×12
Waters ×263
* Residue conservation analysis
PDB id:
3i2b
Name: Lyase
Title: The crystal structure of human 6 pyruvoyl tetrahydrobiopteri
Structure: 6-pyruvoyl tetrahydrobiopterin synthase. Chain: a, d, e, b, c, f, g, h, i, j, k, l. Fragment: unp residues 7-145. Synonym: pts, ptp synthase, ptps. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pts. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.30Å     R-factor:   0.208     R-free:   0.246
Authors: E.Ugochukwu,R.Cocking,E.Pilka,W.W.Yue,J.E.Bray,A.Chaikuad,T. J.Muniz,F.Von Delft,C.Bountra,C.H.Arrowsmith,J.Weigelt,A.Ed U.Oppermann,Structural Genomics Consortium (Sgc)
Key ref: E.Ugochukwu et al. The crystal structure of human 6 pyruvoyl tetrahydrobiopterin synthase. To be published, .
Date:
29-Jun-09     Release date:   28-Jul-09    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q03393  (PTPS_HUMAN) -  6-pyruvoyl tetrahydrobiopterin synthase
Seq:
Struc:
145 a.a.
138 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.4.2.3.12  - 6-pyruvoyltetrahydropterin synthase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
Biopterin Biosynthesis
      Reaction: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8- tetrahydropterin + triphosphate
7,8-dihydroneopterin 3'-triphosphate
= 6-pyruvoyl-5,6,7,8- tetrahydropterin
+ triphosphate
      Cofactor: Mg(2+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cytoplasm   3 terms 
  Biological process     small molecule metabolic process   6 terms 
  Biochemical function     lyase activity     5 terms