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PDBsum entry 3hmx

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protein ligands Protein-protein interface(s) links
Cytokine/immune system PDB id
3hmx
Jmol
Contents
Protein chains
295 a.a. *
176 a.a. *
214 a.a. *
217 a.a. *
Ligands
NAG-NAG-BMA-MAN-
MAN
Waters ×44
* Residue conservation analysis
PDB id:
3hmx
Name: Cytokine/immune system
Title: Crystal structure of ustekinumab fab/il-12 complex
Structure: Interleukin-12 subunit beta. Chain: a. Synonym: il-12b, il-12 subunit p40, cytotoxic lymphocyte ma factor 40 kda subunit, clmf p40, nk cell stimulatory factor nksf2. Engineered: yes. Interleukin-12 subunit alpha. Chain: b. Synonym: il-12a, il-12 subunit p35, cytotoxic lymphocyte ma
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: il12b, nksf2. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek 293. Gene: il12a, nksf1. Other_details: papain digested from mab.
Resolution:
3.00Å     R-factor:   0.215     R-free:   0.303
Authors: J.Luo
Key ref: J.Luo et al. Structural basis for specificity of ustekinumab bindi the p40 subunit of il-12 and il-23. To be published, .
Date:
29-May-09     Release date:   09-Jun-10    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P29460  (IL12B_HUMAN) -  Interleukin-12 subunit beta
Seq:
Struc:
328 a.a.
295 a.a.
Protein chain
Pfam   ArchSchema ?
P29459  (IL12A_HUMAN) -  Interleukin-12 subunit alpha
Seq:
Struc:
219 a.a.
176 a.a.
Protein chain
No UniProt id for this chain
Struc: 214 a.a.
Protein chain
No UniProt id for this chain
Struc: 217 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular region   6 terms 
  Biological process     negative regulation of growth of symbiont in host   63 terms 
  Biochemical function     protein binding     13 terms