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PDBsum entry 3gci

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protein ligands metals links
Hydrolase PDB id
3gci
Jmol
Contents
Protein chain
119 a.a. *
Ligands
VAL-GLY-GLY-VAL-
VAL-ILE-ALA
Metals
_CA
Waters ×93
* Residue conservation analysis
PDB id:
3gci
Name: Hydrolase
Title: Crystal structure of the complex formed between a new isofor phospholipase a2 with c-terminal amyloid beta heptapeptide resolution
Structure: Phospholipase a2 isoform 3. Chain: a. Synonym: phosphatidylcholine 2-acylhydrolase. Heptapeptide from amyloid beta a4 protein. Chain: p. Fragment: unp residues 707-713. Engineered: yes
Source: Naja sagittifera. Andaman cobra. Organism_taxid: 195058. Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Other_details: this peptide was chemically synthesized. Thi sequence occurs naturally in humans.
Resolution:
2.04Å     R-factor:   0.186     R-free:   0.221
Authors: Z.Mirza,G.Vikram,N.Singh,M.Sinha,A.Bhushan,S.Sharma,A.Sriniv P.Kaur,T.P.Singh
Key ref: Z.Mirza et al. Crystal structure of the complex formed between a new isoform of phospholipase a2 with c-Terminal amyloid beta heptapeptide at 2 a resolution. To be published, .
Date:
22-Feb-09     Release date:   10-Mar-09    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P60045  (PA23_NAJSG) -  Acidic phospholipase A2 3 (Fragment)
Seq:
Struc:
126 a.a.
119 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 3 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.3.1.1.4  - Phospholipase A(2).
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate
Phosphatidylcholine
+ H(2)O
= 1-acylglycerophosphocholine
+
carboxylate
Bound ligand (Het Group name = ALA)
matches with 42.86% similarity
      Cofactor: Calcium
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular region   1 term 
  Biological process     lipid metabolic process   3 terms 
  Biochemical function     hydrolase activity     4 terms