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UniProt functional annotation for P0A6M2 | ||
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| UniProt code: P0A6M2. |
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| Organism: | |
Escherichia coli (strain K12). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Function: | |
Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by oxidizing the DsbA protein. PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing (deletion of dsbA/dsbB, treatment with dithiothreitol). MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway. {ECO:0000269|PubMed:22267510, ECO:0000269|PubMed:7688471, ECO:0000269|PubMed:8430071}. |
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| Subcellular location: | |
Cell inner membrane {ECO:0000269|PubMed:7957076, ECO:0000269|PubMed:8430071}; Multi-pass membrane protein {ECO:0000269|PubMed:7957076, ECO:0000269|PubMed:8430071}. |
| Disruption phenotype: | |
Induction of the PhoP/PhoQ two-component regulatory system. {ECO:0000269|PubMed:22267510}. |
| Similarity: | |
Belongs to the DsbB family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=AAA23711.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAA24220.1; Type=Frameshift; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.