UniProt functional annotation for P03428



	UniProt functional annotation for P03428

UniProt code: P03428.

Organism: Influenza A virus (strain A/Puerto Rico/8/1934 H1N1).

Taxonomy: Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina; Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus.

Function: Plays an essential role in transcription initiation and cap- stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Recognizes and binds the 7- methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. In addition, participates in the inhibition of type I interferon induction through interaction with and inhibition of the host mitochondrial antiviral signaling protein MAVS. {ECO:0000255|HAMAP-Rule:MF_04062, ECO:0000269|PubMed:16242167, ECO:0000269|PubMed:17030872, ECO:0000269|PubMed:20538852, ECO:0000269|PubMed:22570712, ECO:0000269|PubMed:23246644, ECO:0000269|PubMed:25043584}.

Subunit: Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA. Interacts (via N-terminus) with PB1 (via C-terminus). Interacts with nucleoprotein NP (via N-terminus). Interacts (via N- terminus) with host MAVS (via N-terminus); this interaction inhibits host innate immune response. {ECO:0000255|HAMAP-Rule:MF_04062, ECO:0000269|PubMed:20538852, ECO:0000269|PubMed:22570712, ECO:0000269|PubMed:23246644, ECO:0000269|PubMed:25043584}.

Subcellular location: Virion {ECO:0000255|HAMAP-Rule:MF_04062}. Host nucleus {ECO:0000255|HAMAP-Rule:MF_04062, ECO:0000269|PubMed:15308710, ECO:0000269|PubMed:20538852}. Host mitochondrion {ECO:0000255|HAMAP- Rule:MF_04062, ECO:0000269|PubMed:15308710, ECO:0000269|PubMed:16242167, ECO:0000269|PubMed:20538852}.

Similarity: Belongs to the influenza viruses PB2 family. {ECO:0000255|HAMAP-Rule:MF_04062, ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Influenza A virus (strain A/Puerto Rico/8/1934 H1N1).
Taxonomy:		Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina; Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus.



Function:		Plays an essential role in transcription initiation and cap- stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Recognizes and binds the 7- methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. In addition, participates in the inhibition of type I interferon induction through interaction with and inhibition of the host mitochondrial antiviral signaling protein MAVS. {ECO:0000255\|HAMAP-Rule:MF_04062, ECO:0000269\|PubMed:16242167, ECO:0000269\|PubMed:17030872, ECO:0000269\|PubMed:20538852, ECO:0000269\|PubMed:22570712, ECO:0000269\|PubMed:23246644, ECO:0000269\|PubMed:25043584}.


Subunit:		Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA. Interacts (via N-terminus) with PB1 (via C-terminus). Interacts with nucleoprotein NP (via N-terminus). Interacts (via N- terminus) with host MAVS (via N-terminus); this interaction inhibits host innate immune response. {ECO:0000255\|HAMAP-Rule:MF_04062, ECO:0000269\|PubMed:20538852, ECO:0000269\|PubMed:22570712, ECO:0000269\|PubMed:23246644, ECO:0000269\|PubMed:25043584}.
Subcellular location:		Virion {ECO:0000255\|HAMAP-Rule:MF_04062}. Host nucleus {ECO:0000255\|HAMAP-Rule:MF_04062, ECO:0000269\|PubMed:15308710, ECO:0000269\|PubMed:20538852}. Host mitochondrion {ECO:0000255\|HAMAP- Rule:MF_04062, ECO:0000269\|PubMed:15308710, ECO:0000269\|PubMed:16242167, ECO:0000269\|PubMed:20538852}.
Similarity:		Belongs to the influenza viruses PB2 family. {ECO:0000255\|HAMAP-Rule:MF_04062, ECO:0000305}.