UniProt functional annotation for Q9XSU0

UniProt code: Q9XSU0.

Organism: Canis familiaris (Dog) (Canis lupus familiaris).
Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
 
Function: Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex (By similarity).
 
Subunit: Component of the 60S ribosome. Component of the GAIT complex. Interacts with EIF4G1 (By similarity).
Ptm: Phosphorylation at Ser-77 is causing release from the ribosome, association with the GAIT complex and subsequent involvement in transcript-selective translation inhibition (By similarity).
Ptm: Citrullinated by PADI4 (By similarity).
Similarity: Belongs to the ribosomal protein L13P family.

Annotations taken from UniProtKB at the EBI.