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PDBsum entry 2zfq
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protein ligands metals Protein-protein interface(s) links
Hydrolase/hydrolase inhibitor PDB id
2zfq

 

 

 

 

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JSmol PyMol  
Contents
Protein chains
27 a.a. *
251 a.a. *
Ligands
GLY-ASP-PHE-GLU-
GLU-ILE-PRO-GLU-
GLU-TYS
45U
BEN
GOL
Metals
_NA ×2
Waters ×179
* Residue conservation analysis
PDB id:
2zfq
Name: Hydrolase/hydrolase inhibitor
Title: Exploring thrombin s3 pocket
Structure: Thrombin light chain. Chain: l. Thrombin heavy chain. Chain: h. Hirudin. Chain: i. Fragment: residues 53-64. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: plasma. Synthetic: yes. Hirudo medicinalis. Organism_taxid: 6421. Other_details: synthetic fragment of hirudin from hirudo medicinalis
Resolution:
1.80Å     R-factor:   0.189     R-free:   0.245
Authors: T.Brandt,B.Baum,A.Heine,G.Klebe
Key ref: T.Brandt et al. Exploring thrombin s3 pocket. To be published, .
Date:
10-Jan-08     Release date:   13-Jan-09    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P00734  (THRB_HUMAN) -  Prothrombin from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		622 a.a.
27 a.a.
Protein chain
Pfam   ArchSchema ?
P00734  (THRB_HUMAN) -  Prothrombin from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		622 a.a.
251 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: Chains L, H: E.C.3.4.21.5  - thrombin.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Preferential cleavage: Arg-|-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B.

 

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