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UniProt functional annotation for P07288 | ||
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| UniProt code: P07288. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum. |
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| Catalytic activity: | |
Reaction=Preferential cleavage: -Tyr-|-Xaa-.; EC=3.4.21.77; |
| Activity regulation: | |
Inhibited by SERPINA5. Activity is strongly inhibited by Zn2+, 100 times more abundant in semen than in serum. This inhibition is relieved by exposure to semenogelins, which are avid zinc binders. {ECO:0000269|PubMed:1725227, ECO:0000269|PubMed:18187150}. |
| Subunit: | |
Forms a heterodimer with SERPINA5. {ECO:0000269|PubMed:18187150}. |
| Subcellular location: | |
Secreted. |
| Similarity: | |
Belongs to the peptidase S1 family. Kallikrein subfamily. {ECO:0000255|PROSITE-ProRule:PRU00274}. |
| Sequence caution: | |
Sequence=AAD14185.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAA32124.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.