PDBsum entry 2zb0

Transferase

PDB id: 2zb0

Contents

Protein chain

349 a.a.

Ligands

GK3

GOL

Waters ×285

References listed in PDB file

Key reference

• Title: Biphenyl amide p38 kinase inhibitors 1: discovery and binding mode.
• Authors: R.M.Angell, P.Bamborough, A.Cleasby, S.G.Cockerill, K.L.Jones, C.J.Mooney, D.O.Somers, A.L.Walker.
• Ref.: Bioorg Med Chem Lett, 2008, 18, 318-323. [DOI no: 10.1016/j.bmcl.2007.10.076]
• PubMed id: 18006306

Abstract

The biphenyl amides (BPAs) are a novel series of p38 MAP kinase inhibitors. The discovery of the series through structure-based focused screening is described, and the binding mode of the compounds is explained with reference to X-ray crystal structures.

Secondary reference #1

• Title: Biphenyl amide p38 kinase inhibitors 2: optimisation and sar.
• Authors: R.M.Angell, T.D.Angell, P.Bamborough, D.Brown, M.Brown, J.B.Buckton, S.G.Cockerill, C.D.Edwards, K.L.Jones, T.Longstaff, P.A.Smee, K.J.Smith, D.O.Somers, A.L.Walker, M.Willson.
• Ref.: Bioorg Med Chem Lett, 2008, 18, 324-328. [DOI no: 10.1016/j.bmcl.2007.10.076]
• PubMed id: 17981461