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PDBsum entry 2z8c
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References listed in PDB file
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Key reference
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Title
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Identification of a key element for hydrogen-Bonding patterns between protein kinases and their inhibitors.
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Authors
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N.Katayama,
M.Orita,
T.Yamaguchi,
H.Hisamichi,
S.Kuromitsu,
H.Kurihara,
H.Sakashita,
Y.Matsumoto,
S.Fujita,
T.Niimi.
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Ref.
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Proteins, 2008,
73,
795-801.
[DOI no: ]
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PubMed id
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Abstract
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In this article, we report crystal structures for inhibitor-kinase complexes in
which the inhibitor has different binding orientations and hydrogen-bonding
patterns with extracellular-signal regulated kinase 2 and insulin receptor
tyrosine kinase. Our crystallographic studies, and sequence and structural
analyses of 532 coordinates of kinases held in the Protein Data Bank, suggest
that the length of the "specificity linker" described here is a key structural
element of the hydrogen-bonding patterns between protein kinases and their
inhibitors. Proteins 2008. (c) 2008 Wiley-Liss, Inc.
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Figure 1.
Figure 1. Schematics showing the binding mode of ligands to
protein kinases. (a) ATP. (b) Purvalanol B in CDK2 (PDB code
1CKP). (c) NU2058 in CDK2 (PDB code 1E1V). Hydrogen bonds are
indicated by broken lines.
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Figure 5.
Figure 5. Key elements for the hydrogen-bonding pattern of an
ATP-mimetic compound. The orientation of R3-O of the group A
kinase is more favorable for that of the group B kinase because
of the difference in the length of the specificity linker.
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The above figures are
reprinted
by permission from John Wiley & Sons, Inc.:
Proteins
(2008,
73,
795-801)
copyright 2008.
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