UniProt functional annotation for Q5SHZ3

UniProt code: Q5SHZ3.

Organism: Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579).
Taxonomy: Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
Function: Cell wall formation. {ECO:0000255|HAMAP-Rule:MF_00047}.
Catalytic activity: ATP + 2 D-alanine = ADP + phosphate + D- alanyl-D-alanine. {ECO:0000255|HAMAP-Rule:MF_00047}.
Cofactor: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Note=Binds 2 magnesium or manganese ions per subunit. {ECO:0000250};
Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. {ECO:0000255|HAMAP-Rule:MF_00047}.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00047}.
Similarity: Belongs to the D-alanine--D-alanine ligase family. {ECO:0000255|HAMAP-Rule:MF_00047}.
Similarity: Contains 1 ATP-grasp domain. {ECO:0000255|HAMAP- Rule:MF_00047}.

Annotations taken from UniProtKB at the EBI.