PDBsum entry 2yuq

Transferase

PDB id: 2yuq

Contents

Protein chain

85 a.a. *

* Residue conservation analysis

PDB id:

2yuq

Name:

Transferase

Title:

Solution structure of the sh3 domain of human tyrosine-protein kinase itk/tsk

Structure:

Tyrosine-protein kinase itk/tsk. Chain: a. Fragment: sh3 domain. Synonym: t-cell-specific kinase, tyrosine-protein kinase lyk, kinase emt. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: itk. Expressed in: cell-free protein synthesis.

NMR struc:

20 models

Authors:

H.Abe,K.Miyamoto,N.Tochio,M.Sato,S.Koshiba,T.Harada,S.Watanabe, T.Kigawa,S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

H.Abe et al. Solution structure of the sh3 domain of human tyrosine-Protein kinase itk/tsk. To be published, .

Date:

06-Apr-07 Release date: 09-Oct-07

Protein chain

Q08881  (ITK_HUMAN) -  Tyrosine-protein kinase ITK/TSK from Homo sapiens

Seq: 620 a.a.

Struc: 85 a.a.*

* PDB and UniProt seqs differ at 7 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site