PDBsum entry 2ysm

Transferase

PDB id: 2ysm

Contents

Protein chain

111 a.a. *

Metals

_ZN ×4

* Residue conservation analysis

PDB id:

2ysm

Name:

Transferase

Title:

Solution structure of the second and third phd domain from histone- lysine n-methyltransferase 2c (kmt2c/mll3)

Structure:

Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog. Chain: a. Fragment: phd domain. Synonym: histone-lysine n-methyltransferase, h3 lysine-4 specific mll3, homologous to alr protein. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: mll3, halr, kiaa1506. Expressed in: cell-free protein synthesis.

NMR struc:

20 models

Authors:

X.R.Qin,F.Hayashi,S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

X.R.Qin et al. Solution structure of the first and second phd domain from myeloid/lymphoid or mixed-Lineage leukemia protein 3 homolog. To be published, .

Date:

03-Apr-07 Release date: 09-Oct-07

Protein chain

Q8NEZ4  (KMT2C_HUMAN) -  Histone-lysine N-methyltransferase 2C from Homo sapiens

Seq: 4911 a.a.

Struc: 111 a.a.*

* PDB and UniProt seqs differ at 13 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.1.1.364 - [histone H3]-lysine(4) N-methyltransferase.
• Reaction: L-lysyl₄-[histone H3] + S-adenosyl-L-methionine = N₆-methyl-L- lysyl₄-[histone H3] + S-adenosyl-L-homocysteine + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site