PDBsum entry 2yr3

Transferase

PDB id: 2yr3

Contents

Protein chain

99 a.a. *

* Residue conservation analysis

PDB id:

2yr3

Name:

Transferase

Title:

Solution structure of the fourth ig-like domain from myosin light chain kinase, smooth muscle

Structure:

Myosin light chain kinase, smooth muscle. Chain: a. Fragment: ig domain. Synonym: mlck, telokin, kinase-related protein, krp. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: mylk. Other_details: cell-free protein synthesis

NMR struc:

20 models

Authors:

X.R.Qin,C.Kurosaki,M.Yoshida,F.Hayahsi,S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

X.R.Qin et al. Solution structure of the fourth ig-Like domain from myosin light chain kinase, Smooth muscle. To be published, .

Date:

02-Apr-07 Release date: 02-Oct-07

Protein chain

Q15746  (MYLK_HUMAN) -  Myosin light chain kinase, smooth muscle from Homo sapiens

Seq: 1914 a.a.

Struc: 99 a.a.*

* PDB and UniProt seqs differ at 7 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.11.18 - [myosin light-chain] kinase.
• Reaction:
  1. L-seryl-[myosin light chain] + ATP = O-phospho-L-seryl-[myosin light chain] + ADP + H⁺
  2. L-threonyl-[myosin light chain] + ATP = O-phospho-L-threonyl-[myosin light chain] + ADP + H⁺
• Cofactor: Ca(2+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site