PDBsum entry 2yjr

Transferase

PDB id: 2yjr

Contents

Protein chain

281 a.a.

Waters ×221

PDB id:

2yjr

Name:

Transferase

Title:

Structure of f1174l mutant anaplastic lymphoma kinase

Structure:

Alk tyrosine kinase receptor. Chain: a. Fragment: kinase domain, residues 1093-1411. Synonym: anaplastic lymphoma kinase, cd246. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Resolution:

1.90Å R-factor: 0.221 R-free: 0.281

Authors:

M.Mctigue,Y.Deng,W.Liu,A.Brooun

Key ref:

M.Mctigue et al. Structure of f1174l mutant anaplastic lymphoma kinase. To be published, .

Date:

23-May-11 Release date: 06-Jun-12

Protein chain

Q9UM73  (ALK_HUMAN) -  ALK tyrosine kinase receptor from Homo sapiens

Seq: 1620 a.a.

Struc: 281 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site