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PDBsum entry 2yhd
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Transcription
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PDB id
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2yhd
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PDB id:
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| Name: |
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Transcription
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Title:
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Human androgen receptor in complex with af2 small molecule inhibitor
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Structure:
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Androgen receptor. Chain: a. Fragment: ligand binding domain, residues 671-919. Synonym: dihydrotestosterone receptor, nuclear receptor subfamily 3 group c member 4. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
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Resolution:
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2.20Å
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R-factor:
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0.211
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R-free:
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0.259
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Authors:
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P.Axeriocilies,N.A.Lack,M.R.Shashinayana,K.H.Chan,A.Yeung,E.Leblanc, E.Guns,P.Rennie,A.Cherkasov
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Key ref:
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P.Axerio-Cilies
et al.
(2011).
Inhibitors of androgen receptor activation function-2 (AF2) site identified through virtual screening.
J Med Chem,
54,
6197-6205.
PubMed id:
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Date:
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28-Apr-11
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Release date:
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21-Sep-11
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PROCHECK
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Headers
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References
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P10275
(ANDR_HUMAN) -
Androgen receptor from Homo sapiens
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Seq:
Struc:
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920 a.a.
249 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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J Med Chem
54:6197-6205
(2011)
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PubMed id:
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Inhibitors of androgen receptor activation function-2 (AF2) site identified through virtual screening.
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P.Axerio-Cilies,
N.A.Lack,
M.R.Nayana,
K.H.Chan,
A.Yeung,
E.Leblanc,
E.S.Guns,
P.S.Rennie,
A.Cherkasov.
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ABSTRACT
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Links
