PDBsum entry 2ygq

Signaling protein

PDB id: 2ygq

Contents

Protein chain

241 a.a.

Ligands

GU4-YYJ

PCF

NAG ×2

FUC

PDB id:

2ygq

Name:

Signaling protein

Title:

Wif domain-epidermal growth factor (egf)-like domains 1-3 of human wnt inhibitory factor 1 in complex with 1,2- dipalmitoylphosphatidylcholine

Structure:

Wnt inhibitory factor 1. Chain: a. Fragment: wif domain-egf-like domains 1-5, residues 35-346. Synonym: wif-1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: n-acetylglucosaminyltransferase i- negative hek 293s gnti(-)cells.

Resolution:

3.95Å R-factor: 0.299 R-free: 0.331

Authors:

T.Malinauskas,A.R.Aricescu,W.Lu,C.Siebold,E.Y.Jones

Key ref:

T.Malinauskas et al. (2011). Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1. Nat Struct Biol, 18, 886-893. PubMed id: 21743455

Date:

19-Apr-11 Release date: 13-Jul-11

Protein chain

Q9Y5W5  (WIF1_HUMAN) -  Wnt inhibitory factor 1 from Homo sapiens

Seq: 379 a.a.

Struc: 241 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Nat Struct Biol 18:886-893 (2011)

PubMed id: 21743455

Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1.

T.Malinauskas, A.R.Aricescu, W.Lu, C.Siebold, E.Y.Jones.

ABSTRACT

No abstract given.