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PDBsum entry 2ygg

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protein ligands metals Protein-protein interface(s) links
Metal binding protein/transport protein PDB id
2ygg
Jmol PyMol
Contents
Protein chains
66 a.a.
146 a.a.
Ligands
MPD
TAM ×3
MRD
Metals
_CA ×4
Waters ×115
PDB id:
2ygg
Name: Metal binding protein/transport protein
Title: Complex of cambr and cam
Structure: Sodium/hydrogen exchanger 1. Chain: a. Fragment: cam binding region, residues 622-689. Synonym: apnh, na(+)/h(+) antiporter\,amiloride-sensitive, na(+)/h(+) exchanger 1, nhe-1, solute carrier family 9 mem nhe1. Engineered: yes. Calmodulin. Chain: b.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Rattus norvegicus. Organism_taxid: 10116.
Resolution:
2.23Å     R-factor:   0.176     R-free:   0.231
Authors: S.Koester,O.Yildiz
Key ref: S.Köster et al. (2011). Structure of human Na+/H+ exchanger NHE1 regulatory region in complex with calmodulin and Ca2+. J Biol Chem, 286, 40954-40961. PubMed id: 21931166 DOI: 10.1074/jbc.M111.286906
Date:
15-Apr-11     Release date:   28-Sep-11    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P19634  (SL9A1_HUMAN) -  Sodium/hydrogen exchanger 1
Seq:
Struc:
 
Seq:
Struc:
815 a.a.
66 a.a.*
Protein chain
Pfam   ArchSchema ?
P62161  (CALM_RAT) -  Calmodulin
Seq:
Struc:
149 a.a.
146 a.a.
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     vesicle   23 terms 
  Biological process     establishment of protein localization in membrane   29 terms 
  Biochemical function     enzyme regulator activity     24 terms  

 

 
DOI no: 10.1074/jbc.M111.286906 J Biol Chem 286:40954-40961 (2011)
PubMed id: 21931166  
 
 
Structure of human Na+/H+ exchanger NHE1 regulatory region in complex with calmodulin and Ca2+.
S.Köster, T.Pavkov-Keller, W.Kühlbrandt, ..Yildiz.
 
  ABSTRACT  
 
No abstract given.

 

 

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