UniProt functional annotation for P98005

UniProt code: P98005.

Organism: Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579).
Taxonomy: Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
 
Function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme a of subunit 1 to the bimetallic center formed by heme a3 and copper B. This cytochrome c oxidase shows proton pump activity across the membrane in addition to the electron transfer.
 
Catalytic activity: 4 ferrocytochrome c + O(2) + 4 H(+) = 4 ferricytochrome c + 2 H(2)O.
Cofactor: Binds 1 copper B ion per subunit.
Cofactor: Binds 2 heme groups per subunit.
Pathway: Energy metabolism; oxidative phosphorylation.
Subunit: Possibly a heterodimer of A-protein (contains: cytochrome c oxidase subunits I and III) and subunit II. The A-protein could also present a precursor form of subunits I and III.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Similarity: In the N-terminal section; belongs to the heme-copper respiratory oxidase family.
Similarity: In the C-terminal section; belongs to the cytochrome c oxidase subunit 3 family.

Annotations taken from UniProtKB at the EBI.