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PDBsum entry 2ydw
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Nuclear protein
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PDB id
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2ydw
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PDB id:
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| Name: |
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Nuclear protein
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Title:
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Crystal structure of the first bromodomain of human brd2 with the inhibitor gw841819x
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Structure:
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Bromodomain-containing protein 2. Chain: a, b, c. Fragment: n-terminal bromodomain, residues 67-200. Synonym: o27.1.1, really interesting new gene 3 protein, human brd2. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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1.90Å
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R-factor:
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0.202
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R-free:
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0.250
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Authors:
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C.Chung,C.Delves,R.Woodward,O.Mirguet,E.Nicodeme
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Key ref:
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C.W.Chung
et al.
(2011).
Discovery and characterization of small molecule inhibitors of the BET family bromodomains.
J Med Chem,
54,
3827-3838.
PubMed id:
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Date:
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24-Mar-11
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Release date:
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15-Jun-11
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PROCHECK
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Headers
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References
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P25440
(BRD2_HUMAN) -
Bromodomain-containing protein 2 from Homo sapiens
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Seq:
Struc:
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801 a.a.
107 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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J Med Chem
54:3827-3838
(2011)
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PubMed id:
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Discovery and characterization of small molecule inhibitors of the BET family bromodomains.
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C.W.Chung,
H.Coste,
J.H.White,
O.Mirguet,
J.Wilde,
R.L.Gosmini,
C.Delves,
S.M.Magny,
R.Woodward,
S.A.Hughes,
E.V.Boursier,
H.Flynn,
A.M.Bouillot,
P.Bamborough,
J.M.Brusq,
F.J.Gellibert,
E.J.Jones,
A.M.Riou,
P.Homes,
S.L.Martin,
I.J.Uings,
J.Toum,
C.A.Clement,
A.B.Boullay,
R.L.Grimley,
F.M.Blandel,
R.K.Prinjha,
K.Lee,
J.Kirilovsky,
E.Nicodeme.
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ABSTRACT
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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A.C.Belkina,
and
G.V.Denis
(2012).
BET domain co-regulators in obesity, inflammation and cancer.
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Nat Rev Cancer,
12,
465-477.
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C.H.Arrowsmith,
C.Bountra,
P.V.Fish,
K.Lee,
and
M.Schapira
(2012).
Epigenetic protein families: a new frontier for drug discovery.
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Nat Rev Drug Discov,
11,
384-400.
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M.A.Dawson,
R.K.Prinjha,
A.Dittmann,
G.Giotopoulos,
M.Bantscheff,
W.I.Chan,
S.C.Robson,
C.W.Chung,
C.Hopf,
M.M.Savitski,
C.Huthmacher,
E.Gudgin,
D.Lugo,
S.Beinke,
T.D.Chapman,
E.J.Roberts,
P.E.Soden,
K.R.Auger,
O.Mirguet,
K.Doehner,
R.Delwel,
A.K.Burnett,
P.Jeffrey,
G.Drewes,
K.Lee,
B.J.Huntly,
and
T.Kouzarides
(2011).
Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia.
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Nature,
478,
529-533.
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PDB code:
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
code is
shown on the right.
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Links
