UniProt functional annotation for P16621



	UniProt functional annotation for P16621

UniProt code: P16621.

Organism: Drosophila melanogaster (Fruit fly).

Taxonomy: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.

Function: Possible cell adhesion receptor (Probable). It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) (PubMed:2554325). It controls motor axon guidance (PubMed:8598047). In the developing eye, has a role in normal axonal targeting of the R7 photoreceptor, where it negatively regulates bdl (PubMed:24174674). Inhibits bdl cell adhesion activity in vitro; this effect is independent of its PTPase function (PubMed:24174674). {ECO:0000269|PubMed:24174674, ECO:0000269|PubMed:2554325, ECO:0000269|PubMed:8598047, ECO:0000305}.

Catalytic activity: Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE- ProRule:PRU10044, ECO:0000269|PubMed:2554325};

Subcellular location: Membrane; Single-pass type I membrane protein.

Tissue specificity: Selectively expressed in a subset of axons and pioneer neurons in the embryo. {ECO:0000269|PubMed:8598047}.

Domain: The extracellular domain (1-1412) is sufficient to inhibit bdl function. {ECO:0000269|PubMed:24174674}.

Disruption phenotype: In the eye, axonal targeting of the R7 photoreceptor is disrupted in approximately 80% of axons. Double knockouts of Lar and bdl partially rescue the R7 axonal targeting phenotype. {ECO:0000269|PubMed:24174674}.

Similarity: Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. {ECO:0000305}.

Sequence caution: Sequence=AAK93409.1; Type=Erroneous initiation; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Drosophila melanogaster (Fruit fly).
Taxonomy:		Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.



Function:		Possible cell adhesion receptor (Probable). It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) (PubMed:2554325). It controls motor axon guidance (PubMed:8598047). In the developing eye, has a role in normal axonal targeting of the R7 photoreceptor, where it negatively regulates bdl (PubMed:24174674). Inhibits bdl cell adhesion activity in vitro; this effect is independent of its PTPase function (PubMed:24174674). {ECO:0000269\|PubMed:24174674, ECO:0000269\|PubMed:2554325, ECO:0000269\|PubMed:8598047, ECO:0000305}.


Catalytic activity:		Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255\|PROSITE- ProRule:PRU10044, ECO:0000269\|PubMed:2554325};
Subcellular location:		Membrane; Single-pass type I membrane protein.
Tissue specificity:		Selectively expressed in a subset of axons and pioneer neurons in the embryo. {ECO:0000269\|PubMed:8598047}.
Domain:		The extracellular domain (1-1412) is sufficient to inhibit bdl function. {ECO:0000269\|PubMed:24174674}.
Disruption phenotype:		In the eye, axonal targeting of the R7 photoreceptor is disrupted in approximately 80% of axons. Double knockouts of Lar and bdl partially rescue the R7 axonal targeting phenotype. {ECO:0000269\|PubMed:24174674}.
Similarity:		Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. {ECO:0000305}.
Sequence caution:		Sequence=AAK93409.1; Type=Erroneous initiation; Evidence={ECO:0000305};