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PDBsum entry 2y9z
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protein dna_rna Protein-protein interface(s) links
Transcription PDB id
2y9z

 

 

 

 

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Contents
Protein chains
287 a.a.
595 a.a.
DNA/RNA
PDB id:
2y9z
Name: Transcription
Title: Chromatin remodeling factor isw1a(del_atpase) in DNA complex
Structure: Imitation switch protein 1 (del_atpase). Chain: a. Fragment: hand, sant, slide domains, residues 763-1129. Synonym: iswi chromatin-remodeling complex atpase isw1, isw1. Engineered: yes. Iswi one complex protein 3. Chain: b. Fragment: core domain containing clb and hlb subdomains, residues 127-749.
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes. Organism_taxid: 4932
Resolution:
3.60Å     R-factor:   0.283     R-free:   0.291
Authors: K.Yamada,T.D.Frouws,B.Angst,D.J.Fitzgerald,C.Deluca,K.Schimmele, D.F.Sargent,T.J.Richmond
Key ref: K.Yamada et al. (2011). Structure and mechanism of the chromatin remodelling factor ISW1a. Nature, 472, 448-453. PubMed id: 21525927
Date:
17-Feb-11     Release date:   20-Apr-11    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P38144  (ISW1_YEAST) -  ISWI chromatin-remodeling complex ATPase ISW1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		1129 a.a.
287 a.a.
Protein chain
Pfam   ArchSchema ?
P43596  (IOC3_YEAST) -  ISWI one complex protein 3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Seq:
Struc: 		 
Seq:
Struc: 		787 a.a.
595 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

DNA/RNA chains
  A-A-C-C-C-G-T-A-T-A-T-A-A-G-C-C-T-A-G-G-C-T-T-A-T-A-T-A-C-G-G 31 bases
  C-C-G-T-A-T-A-T-A-A-G-C-C-T-A-G-G-C-T-T-A-T-A-T-A-C-G-G-G-T-T 31 bases
  A-G-G-C-T-T-A-T-A-T-A-C-G-G-G-T-T-C-A-T-G-C-G 23 bases
  C-G-C-A-T-G-A-A-C-C-C-G-T-A-T-A-T-A-A-G-C-C-T 23 bases

 Enzyme reactions 
   Enzyme class 1: Chain A: E.C.3.6.4.-  - ?????
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
   Enzyme class 2: Chain B: E.C.?
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

 

 
Nature 472:448-453 (2011)
PubMed id: 21525927  
 
 
Structure and mechanism of the chromatin remodelling factor ISW1a.
K.Yamada, T.D.Frouws, B.Angst, D.J.Fitzgerald, C.DeLuca, K.Schimmele, D.F.Sargent, T.J.Richmond.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
23202585 F.Mueller-Planitz, H.Klinker, J.Ludwigsen, and P.B.Becker (2013).
The ATPase domain of ISWI is an autonomous nucleosome remodeling machine.
  Nat Struct Mol Biol, 20, 82-89.  
23334290 S.K.Hota, S.K.Bhardwaj, S.Deindl, Y.C.Lin, X.Zhuang, and B.Bartholomew (2013).
Nucleosome mobilization by ISW2 requires the concerted action of the ATPase and SLIDE domains.
  Nat Struct Mol Biol, 20, 222-229.  
23143334 C.R.Clapier, and B.R.Cairns (2012).
Regulation of ISWI involves inhibitory modules antagonized by nucleosomal epitopes.
  Nature, 492, 280-284.  
22922743 M.Smolle, S.Venkatesh, M.M.Gogol, H.Li, Y.Zhang, L.Florens, M.P.Washburn, and J.L.Workman (2012).
Chromatin remodelers Isw1 and Chd1 maintain chromatin structure during transcription by preventing histone exchange.
  Nat Struct Mol Biol, 19, 884-892.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.

 

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