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PDBsum entry 2y1n
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Ligase/transferase
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PDB id
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2y1n
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PDB id:
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| Name: |
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Ligase/transferase
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Title:
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Structure of c-cbl-zap-70 peptide complex
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Structure:
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E3 ubiquitin-protein ligase. Chain: a, c. Fragment: residues 47-435. Synonym: cbl c-cbl, casitas b-lineage lymphoma proto-oncogene, proto- oncogenE C-cbl, ring finger protein 55, signal transduction protein cbl. Engineered: yes. Tyrosine-protein kinase zap-70 zap-70,70 kda zeta- associated protein, syk-related tyrosine kinase.
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 9606
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Resolution:
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2.00Å
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R-factor:
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0.159
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R-free:
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0.180
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Authors:
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H.Dou,G.J.Sibbet,D.T.Huang
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Key ref:
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H.Dou
et al.
(2012).
Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl.
Nat Struct Biol,
19,
184-192.
PubMed id:
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Date:
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08-Dec-10
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Release date:
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18-Jan-12
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PROCHECK
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Headers
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References
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P22681
(CBL_HUMAN) -
E3 ubiquitin-protein ligase CBL from Homo sapiens
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Seq:
Struc:
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906 a.a.
377 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.2.3.2.27
- RING-type E3 ubiquitin transferase.
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Reaction:
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S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6- ubiquitinyl-[acceptor protein]-L-lysine
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Nat Struct Biol
19:184-192
(2012)
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PubMed id:
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Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl.
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H.Dou,
L.Buetow,
A.Hock,
G.J.Sibbet,
K.H.Vousden,
D.T.Huang.
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ABSTRACT
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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H.Dou,
L.Buetow,
G.J.Sibbet,
K.Cameron,
and
D.T.Huang
(2012).
BIRC7-E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer.
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Nat Struct Mol Biol,
19,
876-883.
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PDB code:
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
code is
shown on the right.
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Links
