PDBsum entry 2y0a

Transferase

PDB id: 2y0a

Contents

Protein chain

300 a.a.

Ligands

MES

Waters ×25

PDB id:

2y0a

Name:

Transferase

Title:

Structure of dapk1 construct residues 1-304

Structure:

Death-associated protein kinase 1. Chain: a. Fragment: kinase catalytic domain, residues 2-304. Synonym: death associated kinase 1, dap kinase 1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

2.60Å R-factor: 0.203 R-free: 0.259

Authors:

H.Yumerefendi,P.J.Mas,N.Dordevic,A.A.Mccarthy,D.J.Hart

Key ref:

H.Yumerefendi et al. Library-Based construct screening of death-Associated protein kinase 1 identifies the minimal calmodulin interaction region and autoinhibitory conformation of catalytic domain. To be published, .

Date:

01-Dec-10 Release date: 14-Dec-11

Protein chain

P53355  (DAPK1_HUMAN) -  Death-associated protein kinase 1 from Homo sapiens

Seq: 1430 a.a.

Struc: 300 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.11.1 - non-specific serine/threonine protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site