PDBsum entry 2xyx

Transcription

PDB id: 2xyx

Contents

Protein chains

261 a.a. *

Ligands

Z00 ×2

BOG ×2

Waters ×31

* Residue conservation analysis

PDB id:

2xyx

Name:

Transcription

Title:

Novel sulfonylthiadiazoles with an unusual binding mode as partial dual peroxisome proliferator-activated receptor (ppar) gamma-delta agonists with high potency and in-vivo efficacy

Structure:

Peroxisome proliferator-activated receptor delta. Chain: a, b. Fragment: ligand binding domain, residues 165-441. Synonym: nuci, nuclear hormone receptor 1, nuclear receptor subfamily 1 group c member 2, peroxisome proliferator-activated receptor beta, ppar-delta, nuc1, ppar-beta. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

2.70Å R-factor: 0.216 R-free: 0.264

Authors:

J.-P.Marquette,M.Mathieu

Key ref:

S.Keil et al. (2011). Sulfonylthiadiazoles with an unusual binding mode as partial dual peroxisome proliferator-activated receptor (PPAR) γ/δ agonists with high potency and in vivo efficacy. Chemmedchem, 6, 633-653. PubMed id: 21400663

Date:

19-Nov-10 Release date: 23-Feb-11

Protein chains

Q03181  (PPARD_HUMAN) -  Peroxisome proliferator-activated receptor delta from Homo sapiens

Seq: 441 a.a.

Struc: 261 a.a.

Enzyme reactions

• Enzyme class: E.C.?

Chemmedchem 6:633-653 (2011)

PubMed id: 21400663

Sulfonylthiadiazoles with an unusual binding mode as partial dual peroxisome proliferator-activated receptor (PPAR) γ/δ agonists with high potency and in vivo efficacy.

S.Keil, H.Matter, K.Schönafinger, M.Glien, M.Mathieu, J.P.Marquette, N.Michot, S.Haag-Diergarten, M.Urmann, W.Wendler.

ABSTRACT

No abstract given.