UniProt functional annotation for Q9VB68



	UniProt functional annotation for Q9VB68

UniProt code: Q9VB68.

Organism: Drosophila melanogaster (Fruit fly).

Taxonomy: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.

Function: Endopeptidase (By similarity). Plays a key role in innate immunity by activating the Toll pathway in response to fungal and Gram- positive bacterial infections, presumably downstream of pattern- recognition receptors (PRR), such as PGRP-SA, GNBP1 and GNBP3, and upstream of spz processing enzyme SPE (PubMed:16631589, PubMed:18724373). {ECO:0000250|UniProtKB:Q9XXV0, ECO:0000269|PubMed:16631589, ECO:0000269|PubMed:18724373}.

Subcellular location: Secreted {ECO:0000305|PubMed:21310954}. Note=Probably secreted in the hemolymph. {ECO:0000305}.

Domain: The clip domain consists of 35-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure. {ECO:0000255|PROSITE-ProRule:PRU01236}.

Ptm: Proteolytically cleaved by a tryspin-like protease which is likely to activate grass. {ECO:0000269|PubMed:21310954}.

Disruption phenotype: Results in increased susceptibility to fungal or Gram-positive bacterial infection and failure to induce the expression of the Toll pathway-activated antifungal peptide Drs (PubMed:18724373). siRNA-mediated knockdown results in increased susceptibility to Gram- positive bacterial infection and severe reduction in the expression of the antifungal peptide Drs (PubMed:16631589). In a protease psh mutant background, complete loss of Drs induction and increased susceptibility to Gram-positive bacterial infection (PubMed:18724373). {ECO:0000269|PubMed:16631589, ECO:0000269|PubMed:18724373}.

Similarity: Belongs to the peptidase S1 family. CLIP subfamily. {ECO:0000255|PROSITE-ProRule:PRU01236}.

Sequence caution: Sequence=AAM52037.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Drosophila melanogaster (Fruit fly).
Taxonomy:		Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.



Function:		Endopeptidase (By similarity). Plays a key role in innate immunity by activating the Toll pathway in response to fungal and Gram- positive bacterial infections, presumably downstream of pattern- recognition receptors (PRR), such as PGRP-SA, GNBP1 and GNBP3, and upstream of spz processing enzyme SPE (PubMed:16631589, PubMed:18724373). {ECO:0000250\|UniProtKB:Q9XXV0, ECO:0000269\|PubMed:16631589, ECO:0000269\|PubMed:18724373}.


Subcellular location:		Secreted {ECO:0000305\|PubMed:21310954}. Note=Probably secreted in the hemolymph. {ECO:0000305}.
Domain:		The clip domain consists of 35-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure. {ECO:0000255\|PROSITE-ProRule:PRU01236}.
Ptm:		Proteolytically cleaved by a tryspin-like protease which is likely to activate grass. {ECO:0000269\|PubMed:21310954}.
Disruption phenotype:		Results in increased susceptibility to fungal or Gram-positive bacterial infection and failure to induce the expression of the Toll pathway-activated antifungal peptide Drs (PubMed:18724373). siRNA-mediated knockdown results in increased susceptibility to Gram- positive bacterial infection and severe reduction in the expression of the antifungal peptide Drs (PubMed:16631589). In a protease psh mutant background, complete loss of Drs induction and increased susceptibility to Gram-positive bacterial infection (PubMed:18724373). {ECO:0000269\|PubMed:16631589, ECO:0000269\|PubMed:18724373}.
Similarity:		Belongs to the peptidase S1 family. CLIP subfamily. {ECO:0000255\|PROSITE-ProRule:PRU01236}.
Sequence caution:		Sequence=AAM52037.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};