PDBsum entry 2xsd

Transcription/DNA

PDB id

2xsd

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Contents

			Protein chain

					128 a.a. *

			DNA/RNA

			Ligands

					EDO ×4

			Waters ×38

* Residue conservation analysis

PDB id:

2xsd

Links

Name:

Transcription/DNA

Title:

Crystal structure of the dimeric oct-6 (pou3f1) pou domain bound to palindromic more DNA

Structure:

5'-d( Ap Tp Gp Cp Ap Tp Gp Ap Gp Gp Ap)-3'. Chain: a. Engineered: yes. 5'-d( Cp Cp Tp Cp Ap Tp Gp Cp Ap Tp Ap)-3'. Chain: b. Engineered: yes. Pou domain, class 3, transcription factor 1. Chain: c. Fragment: residues 240-402.

Source:

Synthetic: yes. Mus musculus. Mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 511693.

Resolution:

2.05Å

R-factor:

0.198

R-free:

0.232

Authors:

R.Jauch,S.H.Choo,C.K.L.Ng,P.R.Kolatkar

Key ref:

R.Jauch et al. (2011). Crystal structure of the dimeric Oct6 (POU3f1) POU domain bound to palindromic MORE DNA. Proteins, 79, 674-677. PubMed id: 21117060

Date:

28-Sep-10

Release date:

20-Oct-10

PROCHECK

	Headers

	References

Protein chain

P21952 (PO3F1_MOUSE) - POU domain, class 3, transcription factor 1 from Mus musculus

Seq: Struc:					449 a.a. 128 a.a.

Key:

PfamA domain

Secondary structure

CATH domain

DNA/RNA chains

		A-T-G-C-A-T-G-A-G-G-A 11 bases
		C-C-T-C-A-T-G-C-A-T-A 11 bases

	Proteins 79:674-677 (2011)
PubMed id: 21117060

Crystal structure of the dimeric Oct6 (POU3f1) POU domain bound to palindromic MORE DNA.
R.Jauch, S.H.Choo, C.K.Ng, P.R.Kolatkar.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

23376973

D.Esch, J.Vahokoski, M.R.Groves, V.Pogenberg, V.Cojocaru, H.Vom Bruch, D.Han, H.C.Drexler, M.J.Araúzo-Bravo, C.K.Ng, R.Jauch, M.Wilmanns, and H.R.Schöler (2013).
A unique Oct4 interface is crucial for reprogramming to pluripotency.

Nat Cell Biol, 15, 295-301.

PDB code:

3l1p

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.