PDBsum entry 2xsd

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protein dna_rna ligands links
Transcription/DNA PDB id
Protein chain
128 a.a. *
EDO ×4
Waters ×38
* Residue conservation analysis
PDB id:
Name: Transcription/DNA
Title: Crystal structure of the dimeric oct-6 (pou3f1) pou domain bound to palindromic more DNA
Structure: 5'-d( Ap Tp Gp Cp Ap Tp Gp Ap Gp Gp Ap)-3'. Chain: a. 5'-d( Cp Cp Tp Cp Ap Tp Gp Cp Ap Tp Ap)-3'. Chain: b. Pou domain, class 3, transcription factor 1. Chain: c. Fragment: residues 240-402. Synonym: octamer-binding transcription factor 6, octamer-bi protein 6, pou domain transcription factor scip, otf-6, oc
Source: Synthetic: yes. Mus musculus. Mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 511693.
2.05Å     R-factor:   0.197     R-free:   0.231
Authors: R.Jauch,S.H.Choo,C.K.L.Ng,P.R.Kolatkar
Key ref: R.Jauch et al. (2011). Crystal structure of the dimeric Oct6 (POU3f1) POU domain bound to palindromic MORE DNA. Proteins, 79, 674-677. PubMed id: 21117060
28-Sep-10     Release date:   20-Oct-10    
Go to PROCHECK summary

Protein chain
Pfam   ArchSchema ?
P21952  (PO3F1_MOUSE) -  POU domain, class 3, transcription factor 1
449 a.a.
128 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     nucleus   1 term 
  Biological process     regulation of transcription, DNA-dependent   1 term 
  Biochemical function     DNA binding     3 terms  


Proteins 79:674-677 (2011)
PubMed id: 21117060  
Crystal structure of the dimeric Oct6 (POU3f1) POU domain bound to palindromic MORE DNA.
R.Jauch, S.H.Choo, C.K.Ng, P.R.Kolatkar.
No abstract given.


Literature references that cite this PDB file's key reference

  PubMed id Reference
23376973 D.Esch, J.Vahokoski, M.R.Groves, V.Pogenberg, V.Cojocaru, H.Vom Bruch, D.Han, H.C.Drexler, M.J.Araúzo-Bravo, C.K.Ng, R.Jauch, M.Wilmanns, and H.R.Schöler (2013).
A unique Oct4 interface is crucial for reprogramming to pluripotency.
  Nat Cell Biol, 15, 295-301.
PDB code: 3l1p
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