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PDBsum entry 2xsd

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protein dna_rna ligands links
Transcription/DNA PDB id
2xsd
Jmol
Contents
Protein chain
128 a.a. *
DNA/RNA
Ligands
EDO ×4
Waters ×38
* Residue conservation analysis
PDB id:
2xsd
Name: Transcription/DNA
Title: Crystal structure of the dimeric oct-6 (pou3f1) pou domain bound to palindromic more DNA
Structure: 5'-d( Ap Tp Gp Cp Ap Tp Gp Ap Gp Gp Ap)-3'. Chain: a. 5'-d( Cp Cp Tp Cp Ap Tp Gp Cp Ap Tp Ap)-3'. Chain: b. Pou domain, class 3, transcription factor 1. Chain: c. Fragment: residues 240-402. Synonym: octamer-binding transcription factor 6, octamer-bi protein 6, pou domain transcription factor scip, otf-6, oc
Source: Synthetic: yes. Mus musculus. Mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Resolution:
2.05Å     R-factor:   0.197     R-free:   0.231
Authors: R.Jauch,S.H.Choo,C.K.L.Ng,P.R.Kolatkar
Key ref: R.Jauch et al. (2011). Crystal structure of the dimeric Oct6 (POU3f1) POU domain bound to palindromic MORE DNA. Proteins, 79, 674-677. PubMed id: 21117060
Date:
28-Sep-10     Release date:   20-Oct-10    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P21952  (PO3F1_MOUSE) -  POU domain, class 3, transcription factor 1
Seq:
Struc:
449 a.a.
128 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     nucleus   1 term 
  Biological process     regulation of transcription, DNA-dependent   1 term 
  Biochemical function     DNA binding     3 terms  

 

 
Proteins 79:674-677 (2011)
PubMed id: 21117060  
 
 
Crystal structure of the dimeric Oct6 (POU3f1) POU domain bound to palindromic MORE DNA.
R.Jauch, S.H.Choo, C.K.Ng, P.R.Kolatkar.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
23376973 D.Esch, J.Vahokoski, M.R.Groves, V.Pogenberg, V.Cojocaru, H.Vom Bruch, D.Han, H.C.Drexler, M.J.Araúzo-Bravo, C.K.Ng, R.Jauch, M.Wilmanns, and H.R.Schöler (2013).
A unique Oct4 interface is crucial for reprogramming to pluripotency.
  Nat Cell Biol, 15, 295-301.
PDB code: 3l1p
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