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Ligand clusters for UniProt code P45983

Ligand clusters for P45983: Mitogen-activated protein kinase 8 OS=Homo sapiens GN=MAPK8 PE=1 SV=2

Top 6 (of 28) ligand clusters
Cluster 1.
20 ligand types
29 ligands
Cluster 2.
3 ligand types
22 ligands
Cluster 3.
2 ligand types
4 ligands
Cluster 4.
2 ligand types
2 ligands
Cluster 5.
3 ligand types
3 ligands
Cluster 6.
3 ligand types
3 ligands
Representative protein: 2h96A  
 

Structures

PDB   Schematic diagram
2h96A    
2xs0A    
4awiA    
3eljA    
4l7fA    
 more ...

 

 Cluster 1 contains 20 ligand types

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Ligand Description


 
1. Ligand: 893 × 1
5-Cyano-N-(2,5-Dimethoxybenzyl)-6-Ethoxypyridine-2- Carboxamide
PDB code: 2h96(A).


 
2. Ligand: 859 × 1
2-({2-[(3-Hydroxyphenyl)amino]pyrimidin-4-Yl}amino) benzamide
PDB code: 2no3(A).


 
3. Ligand: 73Q × 1
6-Chloro-9-Hydroxy-1,3-Dimethyl-1,9-Dihydro-4h- Pyrazolo[3,4-B]quinolin-4-One
PDB code: 2g01(A).


 
4. Ligand: 537 × 1
2,6-Dihydroanthra/1,9-Cd/pyrazol-6-One
PDB code: 1uki(A).


 
5. Ligand: 877 × 1
N-(4-Amino-5-Cyano-6-Ethoxypyridin-2-Yl)-2-(4-Bromo-2, 5-Dimethoxyphenyl)acetamide
PDB code: 2gmx(A).


 
6. Ligand: SO4 × 8
Sulfate ion
PDB codes: 3pze(A), 3v3v(A), 3vug(A), 3vuh(A), 3vui(A),


 
7. Ligand: ANP × 3
Phosphoaminophosphonic acid-Adenylate ester
PDB codes: 2xrw(A), 2xs0(A), 4qtd(A).


 
8. Ligand: 0NR × 1
Methyl 3-(4-{[(1r,2s,3s,5s,7s)-5- Aminotricyclo[3.3.1.1~3,7~]dec-2-Yl]carbamoyl}benzyl)- 4-Oxo-1-
Phenyl-1,4-Dihydro-1,8-Naphthyridine-2- Carboxylate
PDB code: 4e73(A).


 
9. Ligand: 1BJ × 1
Trans-4-{[4-(1h-Indazol-1-Yl)pyrimidin-2- Yl]amino}cyclohexanol
PDB code: 4hys(A).


 
10. Ligand: 1BK × 1
Trans-4-[(4-{4-[3-(Methylsulfonyl)propoxy]-1h-Indazol- 1-Yl}pyrimidin-2-Yl)amino]cyclohexanol
PDB code: 4hyu(A).


 
11. Ligand: 1V5 × 1
N-[1-(4-Fluorophenyl)cyclopropyl]-4-[(Trans-4- Hydroxycyclohexyl)amino]imidazo[1,2-A]quinoxaline-8-
Carboxamide
PDB code: 4l7f(A).


 
12. Ligand: 38Z × 1
(3r)-1-(2-Oxo-2-{4-[4-(Pyrimidin-2-Yl)phenyl]piperazin- 1-Yl}ethyl)-N-[3-(Pyridin-4-Yl)-2h-Indazol-
5- Yl]pyrrolidine-3-Carboxamide
PDB code: 4qtd(A).


 
13. Ligand: AQ2 × 1
N-(1,1-Dioxidotetrahydro-2h-Thiopyran-4-Yl)- 4-[2-(1-Methylethyl)-1h-Pyrrolo[2,3-B]pyridin- 4-
Yl]benzenesulfonamide
PDB code: 4awi(A).


 
14. Ligand: CFK × 1
3-(Carbamoylamino)-5-Phenylthiophene-2-Carboxamide
PDB code: 3pze(A).


 
15. Ligand: EDO × 1
1,2-Ethanediol
PDB code: 4qtd(A).


 
16. Ligand: G1W × 1
Methyl 7-Fluoro-3-{4-[(2-Hydroxyethyl)sulfonyl]benzyl}- 4-Oxo-1-Phenyl-1,4-Dihydroquinoline-2-
Carboxylate
PDB code: 4g1w(A).


 
17. Ligand: GOL × 1
Glycerol
PDB code: 3vuh(A).


 
18. Ligand: GS7 × 1
2-Fluoro-6-{[2-({2-Methoxy-4-[(Methylsulfonyl) methyl]phenyl}amino)-7h-Pyrrolo[2,3-D]pyrimidin-4-
Yl]amino}benzamide
PDB code: 3elj(A).


 
19. Ligand: MYU × 1
3,5,6,7-Tetrahydroxy-2-(3,4-Dihydroxyphenyl)-4h- Chromen-4-One
PDB code: 3v3v(A).

_Mg
 
20. Metal: _MG × 1
PDB code: 4qtd(A).

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 Cluster 2 contains 3 ligand types

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Ligand Description


 
1. Ligand: PRO-LYS-ARG-PRO-THR-THR-LEU-ASN-LEU-PHE × 15
PDB codes: 1ukh(A), 1uki(A), 2g01(A), 2gmx(A), 2h96(A), 2no3(A), 3o17(A), 3o2m(A), 3v3v(A), 3vud(A), 3vug(A), 3vuh(A), 3vui(A), 3vuk(A), 3vul(A).


 
2. Ligand: PRO-LYS-ARG-PRO-THR-THR-LEU-ASN-LEU × 4
PDB codes: 4e73(A), 4g1w(A), 4hys(A), 4hyu(A).


 
3. Ligand: EDO × 3
1,2-Ethanediol
PDB codes: 4qtd(A),

 

 Cluster 3 contains 2 ligand types

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Ligand Description


 
1. Ligand: GOL × 2
Glycerol
PDB codes: 2h96(A),


 
2. Ligand: 46A × 2
N-Butyl-4,6-Dimethyl-N-{[2'-(2h-Tetrazol-5-Yl)biphenyl- 4-Yl]methyl}pyrimidin-2-Amine
PDB codes: 3o2m(A),

 

 Cluster 4 contains 2 ligand types

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Ligand Description


 
1. Ligand: EDO × 1
1,2-Ethanediol
PDB code: 4qtd(A).


 
2. Ligand: EPE × 1
4-(2-Hydroxyethyl)-1-Piperazine ethanesulfonic acid
PDB code: 4qtd(A).

 

 Cluster 5 contains 3 ligand types

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Ligand Description


 
1. Ligand: EDO × 1
1,2-Ethanediol
PDB code: 4qtd(A).


 
2. Ligand: SO4 × 1
Sulfate ion
PDB code: 3pze(A).


 
3. Ligand: TRS × 1
2-Amino-2-Hydroxymethyl-Propane-1,3-Diol
PDB code: 3vum(A).

 

 Cluster 6 contains 3 ligand types

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Ligand Description


 
1. Ligand: EDO × 1
1,2-Ethanediol
PDB code: 4qtd(A).


 
2. Ligand: GOL × 1
Glycerol
PDB code: 2xrw(A).


 
3. Ligand: SO4 × 1
Sulfate ion
PDB code: 4awi(A).

 

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