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UniProt functional annotation for Q63135 | ||
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| UniProt code: Q63135. |
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| Organism: | |
Rattus norvegicus (Rat). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. |
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| Function: | |
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay- accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Seems to act as a costimulatory factor for T-cells. May play a crucial role in early embryonic development by maintaining fetomaternal tolerance. {ECO:0000269|PubMed:15474557, ECO:0000269|PubMed:7534798, ECO:0000269|PubMed:8144902}. |
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| Subunit: | |
Interacts with C3b. {ECO:0000269|PubMed:8144902}. |
| Subcellular location: | |
Membrane; Single-pass type I membrane protein. |
| Similarity: | |
Belongs to the receptors of complement activation (RCA) family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.