PDBsum entry 2xqw

Immune system

PDB id: 2xqw

Contents

Protein chains

294 a.a. *

123 a.a. *

Waters ×193

* Residue conservation analysis

PDB id:

2xqw

Name:

Immune system

Title:

Structure of factor h domains 19-20 in complex with complement c3d

Structure:

Complement c3. Chain: a, b. Fragment: thioester domain, residues 996-1287. Synonym: c3 and pzp-like alpha-2-macroglobulin domain-containing protein 1. Engineered: yes. Mutation: yes. Complement factor h. Chain: c.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expressed in: pichia pastoris. Expression_system_taxid: 4922

Resolution:

2.31Å R-factor: 0.203 R-free: 0.242

Authors:

T.Kajander,M.J.Lehtinen,S.Hyvarinen,A.Bhattacharjee,E.Leung, D.E.Isenman,S.Meri,T.S.Jokiranta,A.Goldman

Key ref:

T.Kajander et al. (2011). Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement. Proc Natl Acad Sci U S A, 108, 2897-2902. PubMed id: 21285368

Date:

07-Sep-10 Release date: 02-Feb-11

Protein chains

P01024  (CO3_HUMAN) -  Complement C3 from Homo sapiens

Seq: 1663 a.a.

Struc: 294 a.a.*

Protein chain

P08603  (CFAH_HUMAN) -  Complement factor H from Homo sapiens

Seq: 1231 a.a.

Struc: 123 a.a.*

* PDB and UniProt seqs differ at 5 residue positions (black crosses)

Proc Natl Acad Sci U S A 108:2897-2902 (2011)

PubMed id: 21285368

Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement.

T.Kajander, M.J.Lehtinen, S.Hyvärinen, A.Bhattacharjee, E.Leung, D.E.Isenman, S.Meri, A.Goldman, T.S.Jokiranta.

ABSTRACT

No abstract given.