PDBsum entry 2xqb

Immune system

PDB id: 2xqb

Contents

Protein chains

105 a.a. *

227 a.a. *

202 a.a. *

Ligands

SO4 ×3

Waters ×66

* Residue conservation analysis

PDB id:

2xqb

Name:

Immune system

Title:

Crystal structure of anti-il-15 antibody in complex with human il-15

Structure:

Interleukin 15. Chain: a. Engineered: yes. Anti-il-15 antibody. Chain: h. Engineered: yes. Anti-il-15 antibody. Chain: l. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293/ebna. Expression_system_cell_line: hek293/ebna

Resolution:

2.60Å R-factor: 0.248 R-free: 0.318

Authors:

D.C.Lowe,S.Gerhardt,A.Ward,D.Hargreaves,M.Anderson,S.Stgallay, K.Vousden,F.Ferraro,R.A.Pauptit,D.Cochrane,D.V.Pattison,C.Buchanan, B.Popovic,D.K.Finch,T.Wilkinson,M.Sleeman,T.J.Vaughan,S.Cruwys, P.R.Mallinder

Key ref:

D.C.Lowe et al. (2011). Engineering a high-affinity anti-IL-15 antibody: crystal structure reveals an α-helix in VH CDR3 as key component of paratope. J Mol Biol, 406, 160-175. PubMed id: 21167836

Date:

01-Sep-10 Release date: 29-Dec-10

Protein chain

P40933  (IL15_HUMAN) -  Interleukin-15 from Homo sapiens

Seq: 162 a.a.

Struc: 105 a.a.

Protein chain

No UniProt id for this chain

Struc: 227 a.a.

Protein chain

No UniProt id for this chain

Struc: 202 a.a.

J Mol Biol 406:160-175 (2011)

PubMed id: 21167836

Engineering a high-affinity anti-IL-15 antibody: crystal structure reveals an α-helix in VH CDR3 as key component of paratope.

D.C.Lowe, S.Gerhardt, A.Ward, D.Hargreaves, M.Anderson, F.Ferraro, R.A.Pauptit, D.V.Pattison, C.Buchanan, B.Popovic, D.K.Finch, T.Wilkinson, M.Sleeman, T.J.Vaughan, P.R.Mallinder.

ABSTRACT

No abstract given.