PDBsum entry 2xn9

Immune system

PDB id: 2xn9

Contents

Protein chains

199 a.a. *

242 a.a. *

215 a.a. *

178 a.a. *

188 a.a. *

13 a.a. *

Ligands

GOL ×4

Metals

_NA

Waters ×280

* Residue conservation analysis

PDB id:

2xn9

Name:

Immune system

Title:

Crystal structure of the ternary complex between human t cell receptor, staphylococcal enterotoxin h and human major histocompatibility complex class ii

Structure:

T cell receptor alpha chain c region. Chain: a. Fragment: extracellular domain, residues 1-95. Engineered: yes. Mutation: yes. Other_details: variable domain trav27 fused to constant domain. T cell receptor beta-1 chain c region. Chain: b. Fragment: extracellular domain, residues 1-130.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Cell: t lymphocyte. Expressed in: escherichia coli. Expression_system_taxid: 469008. Staphylococcus aureus. Organism_taxid: 1280. Expression_system_taxid: 83333.

Resolution:

2.30Å R-factor: 0.224 R-free: 0.272

Authors:

M.Saline,K.E.J.Rodstrom,G.Fischer,V.Y.Orekhov,B.G.Karlsson, K.Lindkvist-Petersson

Key ref:

M.Saline et al. (2010). The structure of superantigen complexed with TCR and MHC reveals novel insights into superantigenic T cell activation. Nat Commun, 1, 119. PubMed id: 21081917 DOI: 10.1038/ncomms1117

Date:

31-Jul-10 Release date: 24-Nov-10

Protein chain

P01848  (TCA_HUMAN) -  T cell receptor alpha chain constant from Homo sapiens

Seq: 140 a.a.

Struc: 199 a.a.*

Protein chain

P01850  (TRBC1_HUMAN) -  T cell receptor beta constant 1 from Homo sapiens

Seq: 176 a.a.

Struc: 242 a.a.*

Protein chain

P0A0M0  (ETXH_STAAU) -  Enterotoxin type H from Staphylococcus aureus

Seq: 241 a.a.

Struc: 215 a.a.

Protein chain

P01903  (DRA_HUMAN) -  HLA class II histocompatibility antigen, DR alpha chain from Homo sapiens

Seq: 254 a.a.

Struc: 178 a.a.

Protein chain

P01911  (2B1F_HUMAN) -  HLA class II histocompatibility antigen, DRB1 beta chain from Homo sapiens

Seq: 266 a.a.

Struc: 188 a.a.*

Protein chain

Q03909  (HEMA_I89A7) -  Hemagglutinin from Influenza A virus (strain A/Equine/Jillin/1/1989 H3N8)

Seq: 571 a.a.

Struc: 13 a.a.

* PDB and UniProt seqs differ at 19 residue positions (black crosses)

DOI no: 10.1038/ncomms1117

Nat Commun 1:119 (2010)

PubMed id: 21081917

The structure of superantigen complexed with TCR and MHC reveals novel insights into superantigenic T cell activation.

M.Saline, K.E.Rödström, G.Fischer, V.Y.Orekhov, B.G.Karlsson, K.Lindkvist-Petersson.

ABSTRACT

No abstract given.