UniProt functional annotation for O95198



	UniProt functional annotation for O95198

UniProt code: O95198.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors. {ECO:0000250, ECO:0000269|PubMed:15715669, ECO:0000269|PubMed:23838290}.

Subunit: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. Interacts with NPTXR and CUL3 (By similarity). Binds actin. Interacts with KLHL12. Interacts (via N- terminus) with FYN (via SH3 domain). {ECO:0000250, ECO:0000269|PubMed:10397770, ECO:0000269|PubMed:15383316, ECO:0000269|PubMed:15715669}.

Subcellular location: Cytoplasm, cytoskeleton. Cell projection, ruffle. Cell projection {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cytoplasm, cytosol. Note=A proportion colocalizes with the actin cytoskeleton. When over-expressed, colocalizes with NPTXR in perinuclear aggresomes (By similarity). {ECO:0000250}.

Tissue specificity: Ubiquitous. Detected throughout the brain. {ECO:0000269|PubMed:10397770}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors. {ECO:0000250, ECO:0000269\|PubMed:15715669, ECO:0000269\|PubMed:23838290}.


Subunit:		Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. Interacts with NPTXR and CUL3 (By similarity). Binds actin. Interacts with KLHL12. Interacts (via N- terminus) with FYN (via SH3 domain). {ECO:0000250, ECO:0000269\|PubMed:10397770, ECO:0000269\|PubMed:15383316, ECO:0000269\|PubMed:15715669}.
Subcellular location:		Cytoplasm, cytoskeleton. Cell projection, ruffle. Cell projection {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cytoplasm, cytosol. Note=A proportion colocalizes with the actin cytoskeleton. When over-expressed, colocalizes with NPTXR in perinuclear aggresomes (By similarity). {ECO:0000250}.
Tissue specificity:		Ubiquitous. Detected throughout the brain. {ECO:0000269\|PubMed:10397770}.